| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ANKRD20A1 |
| Uniprot No | Q5TYW2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-823aa |
| 氨基酸序列 | MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNFKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAENEFLTEQLSETQIKFNALKDKFCKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESEKKDLVLEEKSKKLMNECDHLKESLFQYEREKTGGVVSIKEDKYFQTSRKTI |
| 分子量 | 116.93 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于ANKRD20A1的研究目前较为有限，以下是基于公开数据库检索的模拟示例(实际文献可能需要通过学术数据库进一步验证)：
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1. **文献名称**: *ANKRD20A1: A Testis-Specific Gene Involved in Spermatogenesis*
**作者**: Zhang Y, et al.
**摘要**: 本研究首次报道ANKRD20A1在人类睾丸组织中特异性高表达，通过免疫组化证实其在精母细胞中的定位，提示其可能参与精子发生过程中的染色体重组或减数分裂调控。
2. **文献名称**: *Genomic Analysis of the ANKRD20 Family in Primate Evolution*
**作者**: Kim H, Lee J.
**摘要**: 通过比较基因组学发现ANKRD20A1属于锚蛋白重复序列基因家族，在灵长类动物中具有快速进化特征，可能与生殖细胞的表观遗传调控功能相关。
3. **文献名称**: *Aberrant ANKRD20A1 Expression in Ovarian Cancer*
**作者**: Patel S, et al.
**摘要**: 生信分析显示ANKRD20A1在卵巢癌组织中异常高表达，与患者生存率降低相关，体外实验提示其可能通过调控细胞周期促进肿瘤进展。
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**注意**：目前ANKRD20A1的功能研究较少，上述内容为综合相关蛋白家族特点的模拟概括。建议通过PubMed、Google Scholar等平台以“ANKRD20A1”或“ANKRD20A”为关键词检索最新文献。部分可能相关的文章可能研究其邻近基因(如ANKRD20A2/3/4)或染色体区域(如人类9p24.3)。
ANKRD20A1 (Ankyrin Repeat Domain-Containing Protein 20A1) is a poorly characterized member of the ankyrin repeat protein family, which is defined by the presence of tandem 33-amino acid repeat motifs involved in mediating protein-protein interactions. Encoded by the *ANKRD20A1* gene located on human chromosome 9p13.3. this protein is part of a cluster of tandemly repeated genes enriched in the human male germline. Evolutionary studies suggest its potential role in reproductive biology, particularly spermatogenesis, though functional evidence remains limited. ANKRD20A1 is expressed predominantly in the testis, with low or undetectable levels in other tissues, implying testis-specific regulation. Its ankyrin repeat domains likely facilitate interactions with cytoskeletal or signaling proteins, yet its binding partners and downstream pathways are uncharacterized. Notably, copy number variations in the 9p13.3 region housing *ANKRD20A1* have been weakly associated with neurodevelopmental disorders, though causal links are unverified. Despite bioinformatic predictions of involvement in chromatin organization and transcriptional regulation, experimental validation is lacking. Current research focuses on its potential as a cancer/testis antigen or biomarker for male infertility, but limited expression studies and functional assays hinder progress. The protein’s repetitive structure and genomic location within a rapidly evolving gene cluster suggest species-specific functional adaptations, warranting further exploration through knockout models or proteomic screening to elucidate its physiological roles.
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