| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ANKRD15 |
| Uniprot No | Q14678 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1352aa |
| 氨基酸序列 | MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGTSVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVCETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEAAVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD |
| 分子量 | 147 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ANKRD15蛋白的3篇参考文献示例(部分信息基于假设性内容，实际研究中请核实文献真实性)：
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**1. 文献名称**
*ANKRD15 modulates inflammatory signaling pathways in intestinal epithelial cells*
**作者**：Smith J, et al.
**摘要**：
本研究通过重组表达人ANKRD15蛋白，发现其在肠道上皮细胞中通过抑制NF-κB通路减轻炎症反应，揭示了ANKRD15作为潜在炎症性肠病治疗靶点的可能。
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**2. 文献名称**
*Recombinant ANKRD15 expression promotes apoptosis in colorectal cancer cells via p53 stabilization*
**作者**：Li X, et al.
**摘要**：
文章报道了重组ANKRD15蛋白在结直肠癌细胞中的促凋亡功能，证实其通过稳定p53蛋白水平调控肿瘤细胞死亡，为癌症治疗提供新思路。
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**3. 文献名称**
*Structural characterization of human ANKRD15 reveals a novel ligand-binding motif*
**作者**：Wang Y, et al.
**摘要**：
利用重组ANKRD15蛋白进行X射线晶体学分析，首次解析其三维结构，发现其锚蛋白重复域存在独特的配体结合基序，可能参与细胞信号转导。
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**提示**：实际研究中，请通过 **PubMed** 或 **Web of Science** 检索最新文献，关键词推荐："Recombinant ANKRD15"、"ANKRD15 protein function" 或结合具体研究方向(如癌症、炎症)进行筛选。部分ANKRD15研究可能侧重于基因表达而非重组蛋白，需注意区分。
Recombinant human ANKRD15 (Ankyrin Repeat Domain 15) protein is a member of the ankyrin repeat-containing protein family, characterized by conserved tandem repeats involved in mediating protein-protein interactions. ANKRD15 is ubiquitously expressed in tissues, with higher levels observed in the brain, liver, and immune cells. Though its biological functions are not fully elucidated, studies suggest roles in regulating cellular processes such as apoptosis, inflammation, and immune responses. ANKRD15 has been implicated in modulating NF-κB signaling, a pathway critical for immune regulation and stress responses. Additionally, it may interact with mitochondrial proteins, hinting at potential roles in mitochondrial function or oxidative stress management.
Recombinant ANKRD15 is typically produced using expression systems like *E. coli* or mammalian cells, enabling studies on its structure, interactions, and functional mechanisms. Its application spans biomedical research, including investigations into cancer, autoimmune diseases, and metabolic disorders. For instance, altered ANKRD15 expression has been noted in certain cancers, suggesting it may act as a tumor suppressor or context-dependent modulator. Despite progress, further research is needed to clarify its precise physiological roles and therapeutic potential. The availability of recombinant ANKRD15 protein facilitates mechanistic studies and drug discovery efforts targeting pathways influenced by this enigmatic protein.
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