| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | APOL6 |
| Uniprot No | Q9BWW8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-343aa |
| 氨基酸序列 | MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK EDLKGNIDKL RALADDIDKT HKKFTKANMV ATSTAVISGV MSLLGLALAP ATGGGSLLLS TAGQGLATAA GVTSIVSGTL ERSKNKEAQA RAEDILPTYD QEDREDEEEK ADYVTAAGKI IYNLRNTLKY AKKNVRAFWK LRANPRLANA TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM SAFSLGYDLA TLSKEWKHLK EGARTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT |
| 分子量 | 38 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与重组人载脂蛋白L6(APOL6)相关的代表性文献信息及简要摘要：
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1. **标题**：*"APOL6 mediates lipid transfer and mitochondrial apoptosis"*
**作者**：Smith JR, et al.
**摘要**：该研究揭示APOL6通过促进线粒体膜脂质重构激活BAX/BAK通路，介导紫外线诱导的细胞凋亡。重组APOL6被证实能独立诱发细胞色素C释放。
2. **标题**：*"Structural insights into human APOL6 lipid-binding domain"*
**作者**：Li X, Zhang Y.
**摘要**：通过X射线晶体学解析了APOL6的脂质结合域三维结构，发现其独特的疏水沟槽可特异性结合溶血磷脂酸，为APOL家族蛋白的脂质转运机制提供了分子证据。
3. **标题**：*"APOL6 interacts with viral RNA sensors in innate immunity"*
**作者**：Wang H, et al.
**摘要**：研究发现重组APOL6可与RIG-I信号通路协同激活Ⅰ型干扰素应答，提示其在抗病毒防御中的潜在作用，其功能依赖于N端脂质结合结构域的完整性。
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(注：以上为模拟文献信息，实际研究中APOL6研究文献较少，需以PubMed/Web of Science最新检索为准。)
Recombinant human apolipoprotein L6 (APOL6) is a member of the APOL protein family, which plays diverse roles in lipid metabolism, innate immunity, and cellular homeostasis. APOL6. encoded by the *APOL6* gene on chromosome 22. is primarily expressed in the skin, lungs, and gastrointestinal tract. Unlike its well-studied relatives APOL1 (associated with kidney disease) and APOL3 (involved in lipid transport), APOL6's precise molecular mechanisms remain less understood. It is implicated in promoting apoptosis under stress conditions, possibly through interactions with mitochondrial or endoplasmic reticulum pathways. Studies suggest APOL6 may regulate lipid droplet dynamics and autophagy, linking it to metabolic disorders and pathogen defense. Recombinant APOL6. produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), enables functional studies by providing purified protein for structural analysis, antibody development, and in vitro assays. Recent research highlights its potential role in cancer progression, viral infection responses, and inflammatory diseases, though conflicting evidence exists regarding its pro- or anti-apoptotic effects depending on cellular context. Challenges in APOL6 research include unresolved structural details, tissue-specific expression patterns, and unclear regulatory mechanisms. Its recombinant form remains a critical tool for deciphering its biological significance and therapeutic potential in metabolic, infectious, and neoplastic diseases.
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