| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARMCX3 |
| Uniprot No | Q8BHS6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-379aa |
| 氨基酸序列 | MGYARKVGWVTAGLVIGAGACYCIYRLTRGRKQNKEKMAEGGSGDVDDAGDCSGARYNDWSDDDDDSNESKSIVWYPPWARIGTEAGTRARARARARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMTRELLRAQVPSSLGSLFNKKENKEVILKLLVIFENINDNFKWEENEPTQNQFGEGSLFFFLKEFQVCADKVLGIESHHDFLVKVKVGKFMAKLAEHMFPKSQE |
| 分子量 | 68.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ARMCX3蛋白的3篇示例参考文献(注：文献为模拟示例，实际文献请通过学术数据库查询)：
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1. **文献名称**：*ARMCX3 regulates mitochondrial transport and promotes neuronal development*
**作者**：Li, J., et al. (2018)
**摘要**：研究发现ARMCX3蛋白通过调控线粒体在轴突中的运输，影响神经元突触形成，并揭示了其与微管结合结构域的相互作用机制。
2. **文献名称**：*Loss of ARMCX3 enhances tumor metastasis via modulating Wnt/β-catenin signaling*
**作者**：Chen, Y., et al. (2020)
**摘要**：通过癌症细胞系实验，证明ARMCX3作为肿瘤抑制因子，通过抑制Wnt通路活性影响肿瘤侵袭转移，其低表达与胃癌患者预后不良相关。
3. **文献名称**：*Proteomic analysis identifies ARMCX3 as a novel interactor of Parkinson's disease-related proteins*
**作者**：Wang, T., et al. (2021)
**摘要**：基于质谱的蛋白质互作组学发现ARMCX3与α-synuclein和PINK1存在相互作用，提示其可能参与帕金森病中线粒体质量控制机制。
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建议通过 **PubMed/Google Scholar** 检索关键词“ARMCX3”或“ARM protein family”获取最新文献。如需具体文献协助，可提供更详细的研究方向。
ARM repeat-containing X-linked protein 3 (ARMCX3) is a member of the ARMCX family encoded by genes located on the X chromosome. Characterized by multiple Armadillo (ARM) repeats, these proteins are implicated in diverse cellular processes, including mitochondrial dynamics, intracellular transport, and cell adhesion. ARMCX3 is anchored to mitochondrial membranes through a C-terminal transmembrane domain and interacts with mitochondrial transport machinery, suggesting a role in regulating organelle positioning and morphology. Studies link ARMCX3 to neural development, as its expression is enriched in the brain, particularly in neurons, where it may influence mitochondrial trafficking critical for synaptic function.
Emerging evidence highlights ARMCX3's involvement in cancer biology. It acts as a potential tumor suppressor, with reduced expression observed in gliomas and other malignancies. Mechanistically, ARMCX3 may regulate apoptosis, metabolic reprogramming, and cell migration through interactions with cytoskeletal components or signaling pathways like Wnt/β-catenin. Additionally, its dysregulation has been associated with neurodegenerative conditions, possibly due to impaired mitochondrial quality control.
Recombinant human ARMCX3 protein, typically produced via bacterial or mammalian expression systems, facilitates structural and functional studies. Ongoing research aims to elucidate its precise molecular mechanisms, therapeutic potential, and role in diseases linked to mitochondrial dysfunction.
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