| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARMCX1 |
| Uniprot No | Q9P291 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-453aa |
| 氨基酸序列 | MGRTREAGCVAAGVVIGAGACYCVYRLAWGRDENEKIWDEDEESTDTSEIGVETVKGAKTNAGAGSGAKLQGDSEVKPEVSLGLEDCPGVKEKAHSGSHSGGGLEAKAKALFNTLKEQASAKAGKGARVGTISGNRTLAPSLPCPGGRGGGCHPTRSGSRAGGRASGKSKGKARSKSTRAPATTWPVRRGKFNFPYKIDDILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTKDPIIREKTYNALNNLSVNAENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDFFALLFLGNHFTKIQIMKLIINFTENPAMTRELVSCKVPSELISLFNKEWDREILLNILTLFENINDNIKNEGLASSRKEFSRSSLFFLFKESGVCVKKIKALANHNDLVVKVKVLKVLTKL |
| 分子量 | 75.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于ARMCX1的假设性参考文献示例(注：实际文献需通过数据库核实)：
1. **"ARMCX1 mediates mitochondrial transport and interacts with MIRO1 in neuronal cells"**
*Authors: Smith J, et al. (Journal of Biological Chemistry, 2018)*
摘要：研究揭示了ARMCX1在神经元细胞中线粒体运输中的作用，发现其与MIRO1蛋白直接互作，调控线粒体沿微管的动态分布，影响突触能量供应。
2. **"Downregulation of ARMCX1 promotes glioma cell migration via Wnt/β-catenin signaling"**
*Authors: Li Y, et al. (Oncology Reports, 2020)*
摘要：发现胶质瘤中ARMCX1表达显著降低，通过激活Wnt/β-catenin通路增强肿瘤细胞迁移能力，提示其作为抑制癌症转移的潜在靶点。
3. **"ARMCX1 is targeted by miR-32 to modulate neural differentiation in neuroblastoma"**
*Authors: Chen L, et al. (Neuroscience, 2021)*
摘要：证明miR-32直接靶向抑制ARMCX1表达，影响神经母细胞瘤细胞的分化进程，表明ARMCX1在神经发育中的表观遗传调控作用。
注：以上为假设性示例，真实文献建议通过PubMed或Google Scholar以关键词“ARMCX1”检索近年研究。
**ARMCX1 (Armadillo Repeat-Containing X-Linked Protein 1)** is a member of the ARMCX family, encoded by a gene located on the X chromosome. It is characterized by multiple armadillo (ARM) repeats, structural motifs involved in protein-protein interactions and cellular signaling. ARMCX1 is evolutionarily conserved and predominantly expressed in the brain, suggesting a role in neuronal development or function. Studies link it to mitochondrial dynamics, with evidence implicating its involvement in regulating mitochondrial trafficking and positioning within cells—a critical process for energy distribution in neurons.
Though its exact mechanisms remain unclear, ARMCX1 is hypothesized to act as an adaptor protein, mediating interactions between mitochondria and cytoskeletal components. Research also highlights its potential role in cancer, where altered expression correlates with tumor progression, possibly influencing cell proliferation or apoptosis. Additionally, ARMCX1’s X-chromosome localization raises questions about sex-specific differences in mitochondrial regulation or neurological disorders.
Despite progress, functional redundancy within the ARMCX family (comprising six members in humans) complicates definitive characterization. Knockout models in mice show subtle phenotypes, implying compensatory mechanisms. Ongoing research aims to unravel its specific contributions to cellular homeostasis, neurodevelopment, and disease pathways, offering potential therapeutic insights for neurodegenerative conditions or cancers.
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