Recombinant Human C14orf45 Protein

The human C14orf45 protein, encoded by the chromosome 14 open reading frame 45 gene, remains poorly characterized, with limited functional or structural data available in current literature. This protein is annotated as a conserved hypothetical protein, widely expressed across human tissues, though its physiological role is not yet fully understood. Bioinformatic analyses suggest it may localize to cellular membranes or organelles, potentially participating in intracellular signaling or regulatory processes. Some studies implicate C14orf45 in cancer progression, with altered expression observed in malignancies like glioblastoma and breast cancer, though mechanistic insights are lacking. Recombinant C14orf45 protein is typically produced via bacterial or mammalian expression systems for biochemical studies, enabling antibody development or interaction screening. Structural predictions indicate possible α-helical domains and disordered regions, but experimental validation through crystallography or NMR is absent. Current research focuses on clarifying its molecular interactions, post-translational modifications, and relevance to disease pathways. As an understudied protein, C14orf45 represents both a challenge and an opportunity for uncovering novel biological mechanisms, with potential applications in biomarker discovery or therapeutic targeting pending further functional elucidation.