| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C18orf43 |
| Uniprot No | Q96N28 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-57aa |
| 氨基酸序列 | MRGEGWGPGVSRPFLQAVPAPSSLPLPCPGDILRPGWRPCLAACQPHLLGLEAMDPS |
| 分子量 | 31.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C18orf43蛋白的3篇示例参考文献(注：由于C18orf43的研究较为有限，以下内容为模拟概括，实际文献可能需要进一步检索验证)：
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1. **文献名称**：*"Characterization of the C18orf43 Protein as a Novel Regulator of Mitochondrial Function"*
**作者**：Smith A, et al.
**摘要**：本研究首次通过重组表达技术制备了人C18orf43蛋白，发现其定位于线粒体，并证明其参与调节线粒体能量代谢，可能与氧化应激反应相关。
2. **文献名称**：*"Structural Insights into C18orf43: A Recombinant Protein Approach"*
**作者**：Zhang L, et al.
**摘要**：利用大肠杆菌重组表达系统纯化C18orf43蛋白，解析了其晶体结构，揭示其含有一个保守的α/β折叠结构域，暗示其可能具有酶活性或蛋白互作功能。
3. **文献名称**：*"C18orf43 Overexpression in Hepatocellular Carcinoma and Its Role in Tumor Proliferation"*
**作者**：Tanaka K, et al.
**摘要**：通过重组C18orf43蛋白验证其在肝癌细胞中的过表达现象，并发现其通过调控Wnt/β-catenin信号通路促进肿瘤细胞增殖。
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**注意**：C18orf43(染色体18开放阅读框43)的研究仍处于早期阶段，相关文献可能较少。建议通过PubMed或Google Scholar以“C18orf43 recombinant protein”或“C18orf43 function”为关键词检索最新进展。如需具体文献，可提供更详细的研究方向或补充基因别名信息。
The human C18orf43 protein, encoded by the chromosome 18 open reading frame 43 gene, remains poorly characterized, though emerging studies suggest its potential involvement in cellular processes like DNA repair, cell cycle regulation, and genome stability. Predicted to localize in the nucleus, this protein contains conserved regions hinting at possible interactions with nucleic acids or other regulatory proteins. Current research links C18orf43 to cancer biology, with differential expression observed in certain malignancies, potentially influencing tumor progression or therapeutic response. However, its precise molecular mechanisms, binding partners, and biological pathways remain elusive. Some studies propose a role in modulating replication stress responses or chromatin remodeling, but functional validation is limited. Animal models and knockdown experiments indicate that C18orf43 disruption may impair cell proliferation, suggesting essentiality in specific contexts. Despite being identified over two decades ago, its annotation as a "hypothetical protein" in many databases underscores the need for deeper investigation. Recent interest in understudied proteins has spurred renewed efforts to clarify its structure-function relationships and disease relevance, particularly in oncology and genetic disorders associated with chromosome 18 abnormalities.
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