关键信息
-
基因名
IGF-I R
-
简介
IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (sf9, His-GST) is the recombinant human-derived IGF-I R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- 应用
-
别名
Insulin-like growth factor 1 receptor; IGF-I receptor; CD221; IGF1R
-
种属
Human
-
表达系统
Baculovirus
-
标签
N-His;N-GST
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P08069
-
表达区间
M954-C1367
-
蛋白长度
Partial
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Insulin-like growth factor I receptor (IGF-IR) is a critical transmembrane receptor that mediates the effects of IGF-I, a hormone influencing growth and development in various tissues. The importance of IGF-IR in cellular processes such as proliferation, differentiation, and survival has drawn significant research interest, especially in the context of cancer biology. Aberrant activation of IGF-IR signaling pathways is often associated with various malignancies, making it a potential target for therapeutic interventions. Researchers have been focusing on the development of recombinant IGF-IR proteins to study their structural and functional properties, as well as to facilitate the discovery of IGF-IR inhibitors. These recombinant proteins help in elucidating the receptor's mechanism of action, its interactions with ligands, and downstream signaling pathways. Furthermore, understanding the role of IGF-IR in diseases can lead to the development of targeted therapies, improving treatment strategies for cancer and other IGF-related disorders. The ongoing investigation into recombinant IGF-IR not only enhances our fundamental understanding of cell signaling but also opens new avenues for drug development, potentially leading to more effective treatments in combating diseases associated with IGF-IR dysregulation.
