Recombinant Human C6orf226 Protein

The protein encoded by the human gene C6orf226 (Chromosome 6 Open Reading Frame 226) remains poorly characterized, with limited functional information available in current scientific literature. It is annotated as a hypothetical protein, primarily identified through computational genomic analyses and conserved ortholog studies. The gene is located on chromosome 6 (6q13) and encodes a protein of approximately 200 amino acids, though splice variants may exist. Evolutionary conservation across vertebrates suggests potential biological relevance, but its exact molecular mechanisms and cellular roles are unresolved.  

Bioinformatics predictions indicate possible involvement in intracellular signaling or regulatory pathways, with weak homology to proteins associated with ubiquitination or protein-protein interactions. Some studies link its expression patterns to immune responses, neural tissues, or cancer progression, though these associations are preliminary. For instance, elevated C6orf226 mRNA levels have been observed in certain tumors, hinting at a potential role in oncogenesis or cell proliferation. However, functional validation through knockout models, biochemical assays, or interactome studies is lacking. Current knowledge gaps highlight the need for targeted research to elucidate its structure, post-translational modifications, and participation in physiological or pathological processes. As a poorly understood protein, C6orf226 represents an example of the "dark proteome," underscoring ongoing challenges in annotating human genome-derived proteins.