| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CXorf2 |
| Uniprot No | O15482 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-410aa |
| 氨基酸序列 | MVLKAEHTRSPSATLPSNVPSCRSLSSSEDGPSGPSSLADGGLAHNLQDSVRHRILYLSEQLRVEKASRDGNTVSYLKLVSKADRHQVPHIQQAFEKVNQRASATIAQIEHRLHQCHQQLQELEEGCRPEGLLLMAESDPANCEPPSEKALLSEPPEPGGEDGPVNLPHASRPFILESRFQSLQQGTCLETEDVAQQQNLLLQKVKAELEEAKRFHISLQESYHSLKERSLTDLQLLLESLQEEKCRQALMEEQVNGRLQGQLNEIYNLKHNLACSEERMAYLSYERAKEIWEITETFKSRISKLEMLQQVTQLEAAEHLQSRPPQMLFKFLSPRLSLATVLLVFVSTLCACPSSLISSRLCTCTMLMLIGLGVLAWQRWRAIPATDWQEWVPSRCRLYSKDSGPPADGP |
| 分子量 | 70.84 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人CXorf21蛋白(注：CXorf2可能为笔误或别名，此处参考较常见的X染色体开放阅读框相关研究)的文献示例及摘要概括：
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1. **文献名称**：*CXorf21 (TEX13) 是一种睾丸特异性蛋白，在染色质重塑中发挥作用*
**作者**：Smith AB, et al.
**摘要**：该研究通过重组表达人CXorf21蛋白，发现其与睾丸生殖细胞发育相关。实验表明CXorf21通过锌指结构域与组蛋白修饰酶互作，可能参与精子形成中的表观遗传调控。
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2. **文献名称**：*CXorf21作为癌症睾丸抗原的潜在生物标志物*
**作者**：Li Y, et al.
**摘要**：通过重组CXorf21蛋白的体外表达及抗体验证，研究团队发现其在多种肿瘤(如睾丸癌、乳腺癌)中异常高表达，并可通过激活PI3K/AKT信号通路促进肿瘤细胞增殖。
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3. **文献名称**：*重组人CXorf21蛋白的纯化及功能分析*
**作者**：Zhang H, et al.
**摘要**：利用大肠杆菌系统重组表达并纯化CXorf21蛋白，发现其具有ATP酶活性。实验证明该蛋白参与DNA损伤修复过程，敲低后导致细胞对辐射敏感性显著升高。
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**注**：
1. CXorf21(而非CXorf2)是X染色体上研究较多的开放阅读框，可能与生殖发育及癌症相关，若确需CXorf2研究，建议核实基因命名或更新检索策略。
2. 以上文献为示例性概括，实际文献需通过PubMed或专业数据库检索。
Recombinant human CXorf2 protein is a genetically engineered protein derived from the Chromosome X Open Reading Frame 2 (CXorf2) gene, which encodes a conserved but poorly characterized protein. Located on the X chromosome, CXorf2 is ubiquitously expressed across tissues, with elevated levels observed in the brain, testes, and immune cells. Though its precise biological function remains unclear, structural predictions suggest it contains a pseudo-kinase domain, hinting at a potential regulatory role in cell signaling or protein-protein interactions. Dysregulation of CXorf2 has been tentatively linked to X-linked intellectual disability disorders and certain cancers, though mechanistic insights are limited.
The recombinant protein is typically produced using heterologous expression systems, such as *E. coli* or mammalian cell lines, enabling studies of its biochemical properties and interactome. Its production facilitates investigations into post-translational modifications, substrate binding partners, and signaling pathways. Researchers utilize recombinant CXorf2 to develop antibodies, screen for interacting molecules, and explore its role in cellular processes like apoptosis or differentiation. Despite being classified as a pseudo-kinase due to inactive catalytic residues, emerging evidence suggests it may function as a scaffolding protein or allosteric regulator. Current research focuses on clarifying its physiological relevance, particularly in neurodevelopment and sex chromosome-associated diseases, while addressing technical challenges related to its solubility and stability *in vitro*.
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