| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FLJ10769 |
| Uniprot No | A0A7P0T9D8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-347aa |
| 氨基酸序列 | MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLERAFSLRKAHSIKDMENTLQLVRNIIPPLSSTKHKGQDGRIGVVGGCQEYTGAPYFAAISALKVGADLSHVFCASAAAPVIKAYSPELIVHPVLDSPNAVHEVEKWLPRLHALVVGPGLGRDDALLRNVQGILEVSKARDIPVVIDADGLWLVAQQPALIHGYRKAVLTPNHVEFSRLYDAVLRGPMDSDDSHGSVLRLSQALGNVTVVQKGERDILSNGQQVLVCSQEGSSRRCGGQGDLLSGSLGVLVHWALLAGPQKTNGSSPLLVAAFGACSLTRQCNHQAFQKHGRSTTTSDMIAEVGAAFSKLFET |
| 分子量 | 63 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FLJ10769蛋白的3篇参考文献及其简要摘要(注：由于FLJ10769研究相对较少，以下文献为模拟示例，实际引用时需根据真实文献调整)：
---
1. **文献名称**: "Characterization of recombinant human FLJ10769 as a novel regulator of cell adhesion"
**作者**: Zhang L, Wang Y, et al.
**摘要**: 本研究通过在大肠杆菌中表达重组人FLJ10769蛋白，发现其能够特异性结合整合素β1胞内域，并调控细胞黏附和迁移过程。实验表明FLJ10769可能通过影响细胞骨架重组参与肿瘤转移。
2. **文献名称**: "FLJ10769 interacts with HSP90 and modulates its chaperone activity in vitro"
**作者**: Tanaka K, Suzuki M.
**摘要**: 利用重组表达的人FLJ10769蛋白进行体外结合实验，证明其与热休克蛋白HSP90存在直接相互作用，并通过抑制HSP90的ATP酶活性干扰其对客户蛋白的折叠功能，提示其在蛋白质量控制中的潜在作用。
3. **文献名称**: "Expression and purification of recombinant human FLJ10769 for antibody development"
**作者**: Chen X, Liu R, et al.
**摘要**: 描述了一种在哺乳动物细胞(HEK293)中高效表达可溶性FLJ10769重组蛋白的方法，通过亲和层析纯化获得高纯度蛋白，并成功用于制备单克隆抗体，为后续疾病生物标志物研究奠定基础。
---
**注意**：FLJ10769(现称C17orf64或某些数据库中的其他命名)研究较为小众，若实际文献不足，建议通过UniProt或NCBI Gene数据库查询最新命名及关联研究。实际写作中需通过PubMed/Google Scholar以“FLJ10769”、“C17orf64”、“recombinant protein”等关键词组合检索核实。
Recombinant human FLJ10769 protein is a product of the FLJ10769 gene, which encodes a protein whose full functional characterization remains under investigation. This gene, located on chromosome 11 in humans, is annotated as a hypothetical protein with limited prior functional data, though bioinformatics analyses suggest potential roles in cellular signaling or metabolic regulation. The recombinant form is typically produced using heterologous expression systems (e.g., E. coli, yeast, or mammalian cells) to enable biochemical and functional studies. FLJ10769 contains predicted domains indicative of enzymatic or protein-binding activities, including conserved motifs shared with oxidoreductases and nucleotide-binding proteins. Tissue expression profiling reveals broad but variable mRNA distribution, with higher levels observed in liver, kidney, and neuronal tissues. Emerging studies associate its dysregulation with certain cancers and metabolic disorders, though causal mechanisms remain unconfirmed. As a research tool, recombinant FLJ10769 facilitates exploration of its interactome, substrate specificity, and potential involvement in disease pathways. Its structural elucidation and knockout models may clarify physiological roles, positioning it as a candidate biomarker or therapeutic target. Current challenges include resolving conflicting functional predictions and establishing standardized assays to validate enzymatic or regulatory activities.
×
