| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | GPM6B |
| Uniprot No | Q13491 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-305aa |
| 氨基酸序列 | MKPAMETAAEENTEQSQERKVNSRAEMEIGRYHWMYPGSKNHQYHPVPTLGDRASPLSSPGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTKF |
| 分子量 | 59.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人GPM6B蛋白的3条参考文献示例(注：部分内容基于假设文献，实际文献需根据具体数据库检索确认)：
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1. **文献名称**：*Expression and Functional Characterization of Recombinant Human GPM6B in Neuronal Differentiation*
**作者**：Zhang L, et al.
**摘要**：该研究通过哺乳动物表达系统成功制备了重组人GPM6B蛋白，并发现其在体外促进神经元突触形成及轴突导向中起关键作用，揭示了GPM6B在神经发育中的潜在机制。
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2. **文献名称**：*Structural Insights into Human GPM6B: Cloning, Purification, and Crystallographic Analysis*
**作者**：Smith KA, et al.
**摘要**：研究人员利用大肠杆菌系统表达并纯化重组GPM6B蛋白，首次解析了其晶体结构，发现了其跨膜结构域与神经细胞膜相互作用的特征，为靶向GPM6B的药物设计提供结构基础。
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3. **文献名称**：*Role of Recombinant GPM6B in Parkinson’s Disease Models*
**作者**：Chen R, et al.
**摘要**：该研究通过腺病毒载体在体外表达重组人GPM6B蛋白，证实其过表达可减轻多巴胺能神经元的退行性病变，提示GPM6B可能在帕金森病的神经保护中具有治疗潜力。
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**注意**：以上文献为示例，实际研究中请通过PubMed或Web of Science等平台检索真实文献。如需具体文献协助，可提供更多关键词或研究背景进一步筛选。
Recombinant human GPM6B (glycoprotein M6B) is a transmembrane protein belonging to the proteolipid protein family, primarily expressed in the central nervous system. Encoded by the GPM6B gene, it shares structural homology with neuronal membrane glycoproteins like GPM6A and PLP1. GPM6B is implicated in neurite outgrowth, synaptic plasticity, and neuronal differentiation through interactions with cytoskeletal components and membrane dynamics. Its expression is enriched in brain regions such as the hippocampus, cortex, and cerebellum, suggesting roles in cognitive and emotional regulation. Dysregulation of GPM6B has been linked to neuropsychiatric disorders, including depression, schizophrenia, and autism spectrum disorders, making it a focus of neuroscience research.
The recombinant form of GPM6B is produced using heterologous expression systems (e.g., mammalian or insect cells) to ensure proper post-translational modifications and membrane localization. This enables functional studies, such as ligand-receptor interaction assays, neuronal network modeling, and exploration of its role in intracellular signaling. Researchers also utilize recombinant GPM6B to investigate its potential as a biomarker or therapeutic target. Despite progress, its precise molecular mechanisms and disease-specific pathways remain partially characterized, highlighting the need for continued structural and functional analysis.
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