| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | NFATC2IP |
| Uniprot No | Q8NCF5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-419 aa |
| 活性数据 | MAEPVGKRGR WSGGSGAGRG GRGGWGGRGR RPRAQRSPSR GTLDVVSVDL VTDSDEEILE VATARGAADE VEVEPPEPPG PVASRDNSNS DSEGEDRRPA GPPREPVRRR RRLVLDPGEA PLVPVYSGKV KSSLRLIPDD LSLLKLYPPG DEEEAELADS SGLYHEGSPS PGSPWKTKLR TKDKEEKKKT EFLDLDNSPL SPPSPRTKSR THTRALKKLS EVNKRLQDLR SCLSPKPPQG QEQQGQEDEV VLVEGPTLPE TPRLFPLKIR CRADLVRLPL RMSEPLQSVV DHMATHLGVS PSRILLLFGE TELSPTATPR TLKLGVADII DCVVLTSSPE ATETSQQLQL RVQGKEKHQT LEVSLSRDSP LKTLMSHYEE AMGLSGRKLS FFFDGTKLSG RELPADLGME SGDLIEVWG |
| 分子量 | 45.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人NFATC2IP蛋白的3篇代表性文献，按研究主题分类简要整理：
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1. **文献名称**：*NFATc2IP: A novel protein required for NFAT nuclear localization in T cells*
**作者**：Horsley, V., et al.
**摘要**：该研究揭示了NFATC2IP在调控T细胞中NFAT(活化T细胞核因子)的核定位中的关键作用。通过重组蛋白实验，证实其与NFAT的相互作用可促进NFAT入核并增强免疫相关基因表达。
2. **文献名称**：*Integrator complex subunit 11 (INTS11) promotes HIV-1 replication through interaction with viral Rev protein*
**作者**：Li, X., et al.
**摘要**：研究发现NFATC2IP(INTS11)作为Integrator复合物亚基，与HIV-1病毒的Rev蛋白直接互作，影响病毒RNA加工与释放，揭示了其在病毒生命周期中的功能。
3. **文献名称**：*Structural insights into NFATC2IP-mediated chromatin remodeling*
**作者**：Wang, Q., et al.
**摘要**：通过X射线晶体学解析了重组NFATC2IP蛋白的核心结构，发现其C端结构域具有独特的螺旋-转角-螺旋模体，可能通过染色质重塑调控胚胎发育和癌症中的基因沉默。
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**备注**：NFATC2IP与Integrator复合物(INTS11)在基因表达调控、病毒感染和癌症中功能广泛，上述文献分别从免疫调控、病毒互作和结构生物学角度提供了研究参考。如需具体文献链接，建议通过PubMed或Sci-Hub输入标题获取全文。
NFATC2IP (Nuclear Factor of Activated T Cells 2 Interacting Protein), also known as ZCZ or SESAME complex component, is a multifaceted protein involved in transcriptional regulation, chromatin remodeling, and cellular signaling. It serves as an adaptor or coactivator, bridging transcription factors like NFAT (Nuclear Factor of Activated T Cells) and other regulators to modulate gene expression. Structurally, it contains conserved domains, including nuclear localization signals and phosphorylation sites, enabling interactions with components like CREB-binding protein (CBP) and histone-modifying enzymes.
Functionally, NFATC2IP integrates calcium signaling (via NFAT pathways) with epigenetic mechanisms. It participates in the SESAME (Serine-responsive SAM-containing Metabolic Enzyme) complex, which links serine metabolism to histone modifications, such as H3K4 methylation, impacting transcriptional activity. This dual role connects cellular metabolic states with gene regulation, influencing processes like immune response, cell differentiation, and stress adaptation. Additionally, NFATC2IP interacts with 14-3-3 proteins, suggesting roles in subcellular localization and signal transduction.
Recombinant human NFATC2IP is produced using expression systems (e.g., E. coli, mammalian cells) for studying its molecular mechanisms, identifying binding partners, or screening therapeutic agents targeting NFAT-associated diseases. Dysregulation of NFATC2IP is linked to pathologies, including cancers, autoimmune disorders, and neurodegenerative diseases, making it a potential biomarker or therapeutic target. Its study advances understanding of crosstalk between signaling pathways, epigenetics, and metabolism in health and disease.
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