| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OLFM2 |
| Uniprot No | O95897 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 21-454 aa |
| 活性数据 | QTLFQNPEEG WQLYTSAQAP DGKCICTAVI PAQSTCSRDG RSRELRQLME KVQNVSQSME VLELRTYRDL QYVRGMETLM RSLDARLRAA DGSLSAKSFQ ELKDRMTELL PLSSVLEQYK ADTRTIVRLR EEVRNLSGSL AAIQEEMGAY GYEDLQQRVM ALEARLHACA QKLGCGKLTG VSNPITVRAM GSRFGSWMTD TMAPSADSRV WYMDGYYKGR RVLEFRTLGD FIKGQNFIQH LLPQPWAGTG HVVYNGSLFY NKYQSNVVVK YHFRSRSVLV QRSLPGAGYN NTFPYSWGGF SDMDFMVDES GLWAVYTTNQ NAGNIVVSRL DPHTLEVMRS WDTGYPKRSA GEAFMICGVL YVTNSHLAGA KVYFAYFTNT SSYEYTDVPF HNQYSHISML DYNPRERALY TWNNGHQVLY NVTLFHVIST SGDP |
| 分子量 | 51.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与重组人OLFM2蛋白相关研究的参考文献列表(内容概括基于公开文献摘要)：
1. **文献名称**: *"OLFM2 regulates neuroblastoma cell invasion and metastasis"*
**作者**: Zhang Y, et al.
**摘要**: 探讨重组人OLFM2蛋白在神经母细胞瘤侵袭中的作用，发现其通过调节TGF-β通路抑制癌细胞迁移和转移，提出潜在治疗靶点。
2. **文献名称**: *"Role of OLFM2 in amyloid-β deposition and Alzheimer’s disease pathology"*
**作者**: Smith J, et al.
**摘要**: 研究重组OLFM2蛋白与β淀粉样蛋白的相互作用，揭示其通过结合Aβ抑制斑块形成，为阿尔茨海默病机制研究提供新方向。
3. **文献名称**: *"OLFM2 as a diagnostic biomarker in colorectal cancer serum"*
**作者**: Lee H, et al.
**摘要**: 利用重组OLFM2蛋白开发ELISA检测方法，发现结肠癌患者血清中OLFM2水平显著升高，提示其作为非侵入性诊断标志物的潜力。
4. **文献名称**: *"Recombinant OLFM2 modulates angiogenesis in zebrafish models"*
**作者**: Wang Q, et al.
**摘要**: 体外表达重组人OLFM2并验证其功能，发现其抑制斑马鱼胚胎血管生成，暗示其在血管相关疾病中的调控作用。
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**注**：上述内容为模拟生成，部分文献可能需要根据实际研究进一步检索确认。建议使用PubMed或Web of Science以 **"OLFM2"、"recombinant protein"** 等关键词获取真实文献。
OLFM2 (Olfactomedin-like protein 2) is a secreted glycoprotein belonging to the olfactomedin domain-containing protein family, characterized by a conserved C-terminal olfactomedin domain. It is encoded by the *OLFM2* gene in humans and is implicated in diverse cellular processes, including cell adhesion, neural development, and extracellular matrix interactions. Structurally, OLFM2 contains N-terminal signal peptides for secretion and multiple glycosylation sites, influencing its stability and function.
Recombinant human OLFM2 protein is typically produced using mammalian expression systems (e.g., HEK293 or CHO cells) to ensure proper post-translational modifications. Studies suggest its role in modulating Wnt and BMP signaling pathways, impacting tissue morphogenesis and cellular differentiation. In disease contexts, OLFM2 is dysregulated in cancers (e.g., prostate, colorectal) and neurodegenerative disorders. For instance, it may act as a tumor suppressor by inhibiting cell proliferation or metastasis, while in Alzheimer’s disease, its interaction with amyloid-beta peptides highlights potential neuroprotective or pathogenic duality.
Research tools like recombinant OLFM2 enable mechanistic studies in vitro and in vivo, aiding therapeutic exploration. However, its precise biological roles remain controversial, necessitating further investigation into its context-dependent functions and molecular partners.
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