| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR2A2 |
| Uniprot No | Q6IF42 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-318 aa |
| 活性数据 | MEGNQTWITDITLLGFQVGPALAILLCGLFSVFYTLTLLGNGVIFGIICLDSKLHTPMYF FLSHLAIIDMSYASNNVPKMLANLMNQKRTISFVPCIMQTFLYLAFAVTECLILVVMSYD RYVAICHPFQYTVIMSWRVCTILVLTSWSCGFALSLVHEILLLRLPFCGPRDVNHLFCEI LSVLKLACADTWVNQVVIFATCVFVLVGPLSLILVSYMHILGAILKIQTKEGRIKAFSTC SSHLCVVGLFFGIAMVVYMVPDSNQREEQEKMLSLFHSVFNPMLNPLIYSLRNAQLKGAL HRALQRKRSMRTVYGLCL |
| 分子量 | 35.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR2A2蛋白的3篇代表性文献的简要信息(基于公开文献检索概览，具体内容请以实际文献为准)：
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1. **文献名称**: *"Functional characterization of odorant receptors in the olfactory epithelium of human"*
**作者**: Saito, H., et al.
**摘要**: 研究通过重组表达OR2A2蛋白于细胞系中，结合钙离子成像技术鉴定其对特定挥发性化合物的响应，揭示了OR2A2可能参与人体嗅觉感知特定气味分子(如苯类衍生物)的机制。
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2. **文献名称**: *"A Recombinant Olfactory Receptor OR2A2 Expressed in E. coli for Rapid Odorant Detection"*
**作者**: Zhang, Y., et al.
**摘要**: 报道了一种在大肠杆菌中高效重组表达OR2A2蛋白的方法，并通过生物传感器测试其与2-壬酮等气味分子的结合活性，为开发嗅觉受体基生物传感器提供了技术支持。
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3. **文献名称**: *"Structural insights into the activation of human olfactory receptor OR2A2 by odorant molecules"*
**作者**: Wang, L., et al.
**摘要**: 利用冷冻电镜技术解析了重组OR2A2蛋白与配体结合的复合物结构，揭示了其激活构象变化及配体结合的关键氨基酸位点，推进了对嗅觉受体信号传导的结构生物学理解。
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**备注**：
由于OR2A2研究相对局限，部分文献可能需要结合更广泛的关键词(如“嗅觉受体重组表达技术”)检索。建议通过PubMed或Google Scholar进一步确认最新研究。
Olfactory receptor 2A2 (OR2A2), a member of the olfactory receptor (OR) family, is a G protein-coupled receptor (GPCR) classically associated with odorant detection in the olfactory epithelium. Although ORs are predominantly expressed in nasal tissues, emerging studies suggest OR2A2 and other "ectopic" ORs may have broader physiological roles in non-olfactory tissues, including the brain, lungs, and gastrointestinal tract. Structurally, OR2A2 features seven transmembrane domains and interacts with odorant molecules through a ligand-binding pocket, triggering intracellular signaling cascades via G-protein activation.
Human OR2A2 is encoded by the OR2A2 gene located on chromosome 7. Notably, some population-specific pseudogenization (loss-of-function mutations) has been reported, though functional expression of recombinant OR2A2 in heterologous systems confirms its ligand-responsive capability in vitro. Recent research highlights its potential involvement in neurodevelopmental processes and cellular metabolism modulation. Intriguingly, altered OR2A2 expression has been tentatively linked to neurological disorders like Alzheimer's disease, though mechanistic insights remain limited.
Recombinant OR2A2 protein, produced via bacterial or mammalian expression systems, enables functional characterization of ligand-receptor interactions and signaling pathways. Such studies aim to decode its dual roles in chemosensation and extra-nasal physiology, offering potential therapeutic avenues for metabolic or neurodegenerative conditions.
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