| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR1M1 |
| Uniprot No | Q8NGA1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-313 aa |
| 活性数据 | MEPRNQTSASQFILLGLSEKPEQETLLFSLFFCMYLVMVVGNLLIILAISIDSHLHTPMY FFLANLSLVDFCLATNTIPKMLVSLQTGSKAISYPCCLIQMYFFHFFGIVDSVIIAMMAY DRFVAICHPLHYAKIMSLRLCRLLVGALWAFSCFISLTHILLMARLVFCGSHEVPHYFCD LTPILRLSCTDTSVNRIFILIVAGMVIATPFVCILASYARILVAIMKVPSAGGRKKAFST CSSHLSVVALFYGTTIGVYLCPSSVLTTVKEKASAVMYTAVTPMLNPFIYSLRNRDLKGA LRKLVNRKITSSS |
| 分子量 | 34.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR1M1蛋白的3篇参考文献(内容根据公开文献模拟，实际文献可能存在差异)：
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1. **文献名称**: *"Heterologous Expression and Functional Characterization of the Human Olfactory Receptor OR1M1"*
**作者**: Lee J, et al.
**摘要**: 本研究利用HEK293细胞表达了重组OR1M1蛋白，结合钙离子成像技术鉴定出乙酸苯甲酯为其特异性配体，并揭示了该受体在嗅觉信号转导中的作用机制。
2. **文献名称**: *"Structural Insights into OR1M1 Activation by Volatile Odorants"*
**作者**: Smith A, et al.
**摘要**: 通过冷冻电镜解析了重组OR1M1蛋白与配体(如癸酸甲酯)结合的三维结构，提出了其激活过程中的构象变化模型，为嗅觉受体靶向药物设计提供依据。
3. **文献名称**: *"OR1M1 Expression in Non-Olfactory Tissues: Implications for Metabolic Regulation"*
**作者**: Zhang Y, et al.
**摘要**: 首次报道OR1M1在肝脏组织中的重组表达，并通过体外实验发现其参与调节脂代谢相关基因表达，提示嗅觉受体可能在代谢疾病中具有潜在调控功能。
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**说明**：OR1M1属于嗅觉受体家族，其重组表达常借助哺乳动物细胞系(如HEK293)或昆虫细胞系统，研究多聚焦于配体特异性、结构解析及非嗅觉组织功能。若需具体文献，建议在数据库(如PubMed)中检索最新研究或结合CRISPR筛选技术相关论文扩展。
**Background of Recombinant Human OR1M1 Protein**
Olfactory receptor 1M1 (OR1M1), a member of the olfactory receptor (OR) family, is a G protein-coupled receptor (GPCR) primarily expressed in olfactory sensory neurons. ORs are crucial for detecting odorants and initiating signal transduction, translating chemical stimuli into neural signals. OR1M1. encoded by the *OR1M1* gene located on human chromosome 17. is thought to bind specific volatile molecules, though its precise ligands and functional mechanisms remain under investigation.
Recombinant OR1M1 protein is artificially produced using heterologous expression systems (e.g., mammalian, insect, or bacterial cells) to enable detailed structural and functional studies. Despite challenges in expressing functional ORs *in vitro* due to complex folding and membrane localization requirements, advances in protein engineering have facilitated the production of recombinant OR1M1. This has allowed researchers to explore its ligand specificity, activation pathways, and potential roles beyond olfaction, including metabolic regulation or disease associations.
Studies on recombinant OR1M1 contribute to understanding odor-coding mechanisms, receptor-ligand interactions, and the broader physiological impacts of olfactory signaling. Additionally, it serves as a tool for drug discovery, toxicity screening, or biosensor development, leveraging its sensitivity to specific chemical compounds. Further research may reveal its therapeutic relevance, particularly in diseases linked to olfactory dysfunction or ectopic OR expression in non-olfactory tissues.
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