| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR6C3 |
| Uniprot No | Q9NZP0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-311 aa |
| 活性数据 | MNHTMVTEFVLLGLSDDPDLQIVIFLFLFITYILSVTGNLTIITLTFVDSHLQTPMYFFL RNFSFLEISFTTVCIPRFLGAIITRNKTISYNNCAAQLFFFIFMGVTEFYILTAMSYDRY VAICKPLHYTSIMNRKLCTLLVLCAWLSGFLTIFPPLMLLLQLDYCASNVIDHFACDYFP LLQLSCSDTWLLEVIGFYFALVTLLFTLALVILSYMYIIRTILRIPSASQRKKAFSTCSS HMIVISISYGSCIFMYANPSAKEKASLTKGIAILNTSVAPMLNPFIYTLRNQQVKQAFKN VVHKVVFYANQ |
| 分子量 | 35.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR6C3蛋白的相关文献简要整理（文献信息为虚构示例，仅供格式参考）：
1. **《Structural analysis of olfactory receptor OR6C3 reveals ligand-binding mechanism》**
- 作者：Li, X. et al.
- 摘要：通过冷冻电镜解析OR6C3蛋白的三维结构，发现其结合特定挥发性小分子的活性位点，为嗅觉受体信号转导机制提供新见解。
2. **《OR6C3 overexpression promotes prostate cancer progression via MAPK/ERK pathway activation》**
- 作者：Chen, Y. et al.
- 摘要：研究发现OR6C3在前列腺癌中异常高表达，重组OR6C3蛋白体外实验证实其通过ERK磷酸化促进肿瘤细胞增殖和迁移。
3. **《Non-olfactory role of OR6C3 in human keratinocyte differentiation》**
- 作者：Wang, L. et al.
- 摘要：首次报道OR6C3在皮肤角质细胞中的表达，重组蛋白实验显示其通过调控钙离子通道影响角质细胞分化，提示潜在皮肤屏障功能。
4. **《OR6C3 as a novel therapeutic target for neuroblastoma: A drug screening study》**
- 作者：Zhang, R. et al.
- 摘要：利用重组OR6C3蛋白进行高通量药物筛选，发现小分子抑制剂Compound-X可阻断OR6C3介导的肿瘤生长信号通路。
（注：上述文献内容为模拟生成，实际研究请参考真实数据库如PubMed。）
The human olfactory receptor OR6C3 is a member of the olfactory receptor (OR) family, which constitutes the largest subset of G protein-coupled receptors (GPCRs). These receptors are primarily located in the olfactory epithelium and play a central role in detecting odorant molecules, enabling the sense of smell. OR6C3 is encoded by the OR6C3 gene, situated on chromosome 12 in humans. Like other olfactory receptors, it features a seven-transmembrane domain structure and couples with intracellular G-proteins to trigger signal transduction pathways upon ligand binding. While its specific ligands and physiological roles remain partially characterized, emerging studies suggest that OR6C3 may have functions beyond olfaction, including potential involvement in cellular processes such as proliferation and differentiation. Recent research has also explored its ectopic expression in non-olfactory tissues, hinting at possible roles in diseases like cancer. Recombinant OR6C3 protein, produced via heterologous expression systems (e.g., mammalian or bacterial cells), is instrumental for structural studies, ligand screening, and functional assays. This recombinant tool aids in deciphering its activation mechanisms and therapeutic potential, bridging gaps between genetic data and biochemical understanding.
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