| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR6B3 |
| Uniprot No | Q8NGW1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-331 aa |
| 活性数据 | MSGENVTRVGTFILVGFPTAPGLQYLLFLLFLLTYLFVLVENLAIILTVWSSTSLHRPMY YFLSSMSFLEIWYVSDITPKMLEGFLLQQKRISFVGCMTQLYFFSSLVCTECVLLASMAY DRYVAICHPLRYHVLVTPGLCLQLVGFSFVSGFTISMIKVCFISSVTFCGSNVLNHFFCD ISPILKLACTDFSTAELVDFILAFIILVFPLLATMLSYAHITLAVLRIPSATGCWRAFFT CASHLTVVTVFYTALLFMYVRPQAIDSRSSNKLISVLYTVITPILNPLIYCLRNKEFKNA LKKAFGLTSCAVEGRLSSLLELHLQIHSQPL |
| 分子量 | 37.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为假设性的参考文献示例，基于OR6B3蛋白可能的研究方向构造（建议通过学术数据库如PubMed获取真实文献）：
1. **文献名称**：*Structural Insights into the Olfactory Receptor OR6B3 and Its Ligand Specificity*
**作者**：Garcia, A. et al.
**摘要**：通过冷冻电镜解析了OR6B3蛋白的三维结构，揭示了其与特定挥发性有机分子的结合模式，为嗅觉受体家族的功能研究提供结构基础。
2. **文献名称**：*OR6B3 Expression in Non-Olfactory Tissues: Implications for Prostate Cancer Biomarkers*
**作者**：Smith, J. et al.
**摘要**：研究发现OR6B3在前列腺癌组织中异常高表达，提示其可能作为诊断标志物或治疗靶点，拓展了嗅觉受体在非嗅觉系统中的功能认知。
3. **文献名称**：*Genetic Variants of OR6B3 and Their Association with Neurodegenerative Disorders*
**作者**：Li, X. et al.
**摘要**：全基因组关联分析表明OR6B3基因多态性与阿尔茨海默病风险相关，推测其可能通过影响嗅觉信号通路参与神经退行性过程。
4. **文献名称**：*Functional Characterization of OR6B3 in Odorant Recognition*
**作者**：Mainland, T. et al.
**摘要**：体外实验证实OR6B3对含硫化合物（如腐败气味分子）具有高亲和力，揭示了其在环境气味感知中的潜在作用。
**注意**：以上文献为假设性构造，实际研究需查阅权威数据库。建议使用关键词“OR6B3”、“olfactory receptor 6B3”在PubMed或Google Scholar中检索最新成果。
The olfactory receptor OR6B3, encoded by the OR6B3 gene, is a member of the G protein-coupled receptor (GPCR) superfamily and belongs to the olfactory receptor subfamily 6B. It is predominantly expressed in olfactory sensory neurons, where it participates in detecting and transducing odorant signals by binding to specific volatile molecules. Structurally, OR6B3 features seven transmembrane helices, a characteristic GPCR architecture, with extracellular N-terminal and intracellular C-terminal domains. While its precise endogenous ligands remain under investigation, olfactory receptors like OR6B3 are hypothesized to recognize a wide range of odorants, contributing to the combinatorial coding of smells.
Recombinant OR6B3 protein is typically produced in heterologous systems (e.g., mammalian or insect cell lines) to enable functional studies, as native expression is low and tissue-specific. This engineered protein allows researchers to probe its ligand-binding specificity, activation mechanisms, and downstream signaling pathways (e.g., cAMP-mediated cascades). Beyond olfaction, OR6B3 has been detected in non-olfactory tissues, suggesting potential roles in chemosensation-independent processes, such as cellular communication or disease pathways. Current research focuses on its therapeutic relevance, including associations with metabolic disorders or cancer, though evidence remains preliminary. Further exploration of recombinant OR6B3 could illuminate novel biological functions and drug-target opportunities.
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