| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PALM2 |
| Uniprot No | Q8IXS6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-376 aa |
| 活性数据 | MEMAEAELHK ERLQAIAEKR KRQTEIEGKR QQLDEQILLL QHSKSKVLRE KWLLQGIPAG TAEEEEARRR QSEEDEFRVK QLEDNIQRLE QEIQTLESEE SQISAKEQII LEKLKETEKS FKDFQKGFSS TDGAVYAMEI NVEKDKQTGE TKILSTSTIG PEGVHQKGVK VYDDGTKVVY EVRSGGTVVE NGVHKLSTKD VEELIQKAGQ SSLGGGHVSE RTVIADGSLS HPKEHMLCKE AKLEMVHKSR KDHSSGNPGQ QAQAPSAAGP EANLDQPVTM IFMGYQNIED EEETKKVLGY DETIKAELVL IDEDDEKSLR EKTVTDVSTI DGNAAELVSG RPVSDTTEPS SPEGKEESLA TEPAPGTQKK KRCQCC |
| 分子量 | 122.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是围绕“PALM2蛋白”的模拟参考文献示例(注：实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *Structural Insights into PALM2-mediated Neuronal Membrane Remodeling*
**作者**: Chen, L. et al.
**摘要**: 本研究通过X射线晶体学解析了重组人PALM2蛋白的C端结构域，揭示了其与细胞膜磷脂相互作用的分子机制，提出PALM2通过寡聚化参与突触膜的动态重塑。
2. **文献名称**: *PALM2 Expression Correlates with Alzheimer’s Disease Pathology in Mouse Models*
**作者**: Gupta, R. & Lee, S.
**摘要**: 利用转基因小鼠模型，发现PALM2在阿尔茨海默病早期大脑中表达显著上调，敲除PALM2可减缓淀粉样斑块沉积，提示其作为神经退行性疾病潜在生物标志物。
3. **文献名称**: *Recombinant PALM2 Production in E. coli: Optimization and Functional Characterization*
**作者**: Kim, J. et al.
**摘要**: 报道了一种高效的大肠杆菌表达系统，用于可溶性重组PALM2蛋白的纯化，并通过体外实验证明其结合膜脂质及调控细胞骨架蛋白的能力。
4. **文献名称**: *PALM2 Interaction with Synaptic Proteins: Implications for Autism Spectrum Disorders*
**作者**: Wang, Y. & Zhang, H.
**摘要**: 通过免疫共沉淀筛选发现PALM2与突触前蛋白复合物(如Neurexin)相互作用，基于患者样本的基因分析支持PALM2突变与自闭症谱系障碍的相关性。
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**说明**：上述文献为模拟示例，真实研究请通过PubMed、Web of Science或Google Scholar等平台，以关键词“PALM2 protein”、“Paralemmin-2”或“重组PALM2”进行检索。
Recombinant human PALM2 (Paralemmin-2) protein is a genetically engineered version of the endogenous PALM2 protein, which belongs to the paralemmin family of membrane-associated proteins. Naturally expressed in neuronal and endocrine tissues, PALM2 plays a critical role in cell membrane dynamics, particularly in shaping plasma membrane subdomains and regulating synaptic vesicle trafficking. It contains a C-terminal prenylation motif, facilitating its attachment to lipid membranes, and interacts with cytoskeletal components to influence membrane curvature and vesicle fusion processes.
The recombinant form is typically produced using heterologous expression systems like *E. coli* or mammalian cell cultures, enabling scalable purification for research applications. Studying recombinant PALM2 helps elucidate its molecular functions, including its involvement in neurotransmitter release, cell adhesion, and neuronal plasticity. Dysregulation of PALM2 has been linked to neurological disorders, such as schizophrenia and Alzheimer’s disease, making it a potential biomarker or therapeutic target.
In biotechnological contexts, recombinant PALM2 aids in deciphering membrane-protein interactions and high-throughput drug screening. Its engineered variants also serve as tools to explore post-translational modifications, such as palmitoylation, which govern its membrane localization and activity. Overall, recombinant PALM2 bridges structural studies and functional assays, advancing both basic neurobiology and translational research.
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