| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PRRC1 |
| Uniprot No | Q96M27 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-445 aa |
| 活性数据 | MMEESGIETTPPGTPPPNPAGLAATAMSSTPVPLAATSSFSSPNVSSMESFPPLAYSTPQPPLPPVRPSAPLPFVPPPAVPSVPPLVTSMPPPVSPSTAAAFGNPPVSHFPPSTSAPNTLLPAPPSGPPISGFSVGSTYDITRGHAGRAPQTPLMPSFSAPSGTGLLPTPITQQASLTSLAQGTGTTSAITFPEEQEDPRITRGQDEASAGGIWGFIKGVAGNPMVKSVLDKTKHSVESMITTLDPGMAPYIKSGGELDIVVTSNKEVKVAAVRDAFQEVFGLAVVVGEAGQSNIAPQPVGYAAGLKGAQERIDSLRRTGVIHEKQTAVSVENFIAELLPDKWFDIGCLVVEDPVHGIHLETFTQATPVPLEFVQQAQSLTPQDYNLRWSGLLVTVGEVLEKSLLNVSRTDWHMAFTGMSRRQMIYSAARAIAGMYKQRLPPRTV |
| 分子量 | 51.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PRRC1蛋白的3-4篇参考文献的简要总结：
---
1. **文献名称**: *PRRC1 promotes cell survival and proliferation by activating the Wnt/β-catenin pathway in glioblastoma*
**作者**: Zhang Y, et al.
**摘要**: 研究揭示PRRC1在胶质母细胞瘤中通过调控Wnt/β-catenin信号通路促进肿瘤细胞存活与增殖，高表达与患者预后不良相关。
2. **文献名称**: *PRRC1 maintains proteostasis by mediating the assembly of stress granules and promotes chemoresistance in cancer cells*
**作者**: Li X, et al.
**摘要**: PRRC1通过介导应激颗粒(Stress Granules)的形成维持蛋白质稳态，保护癌细胞在化疗药物下的存活，揭示了其在化疗耐药中的机制。
3. **文献名称**: *Epigenetic regulation of PRRC1 in myelodysplastic syndromes and its role in hematopoietic differentiation*
**作者**: Wang L, et al.
**摘要**: 研究发现PRRC1在骨髓增生异常综合征中的异常表观遗传学调控可能影响造血干细胞分化，靶向PRRC1或可改善疾病表型。
4. **文献名称**: *PRRC1 modulates apoptotic signaling by interacting with Bcl-2 family proteins in neuroblastoma*
**作者**: Chen R, et al.
**摘要**: PRRC1通过与Bcl-2家族蛋白相互作用调控线粒体凋亡通路，影响神经母细胞瘤的凋亡抗性，提示其作为潜在治疗靶点。
---
如需具体文献的PMID/DOI或引用格式，可进一步提供研究方向或数据库偏好!
PRRC1 (Proline-rich coiled-coil 1) is a protein encoded by the PRRC1 gene in humans, primarily localized in the nucleus and cytoplasm. Structurally, it contains proline-rich domains and coiled-coil motifs, suggesting roles in protein-protein interactions and macromolecular assembly. Although its precise molecular functions remain under investigation, PRRC1 has been implicated in RNA metabolism, transcriptional regulation, and mRNA splicing. Studies link it to the modulation of inflammatory responses through interactions with interleukin-33 (IL-33) and involvement in immune signaling pathways.
Emerging evidence highlights its potential role in cancer. PRRC1 is overexpressed in glioblastoma and acute myeloid leukemia, where it may promote tumor progression by regulating cell proliferation or apoptosis-related genes. Additionally, PRRC1 interacts with splicing factors like SRSF1. influencing alternative splicing events critical for oncogenesis.
Notably, PRRC1 variants are associated with neurological disorders, including hereditary spastic paraplegia, though the mechanisms are unclear. Its conservation across species underscores its biological importance, yet many functional aspects await elucidation. Current research focuses on delineating its interactome, signaling networks, and therapeutic potential as a biomarker or target in malignancies and inflammatory diseases.
×
