| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | REXO1L1 |
| Uniprot No | Q8IX06 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-675 aa |
| 活性数据 | MLRATAPCWF PPGYPEAKKV AEEAALEASR HLGGEQSQAG APEGSKMLRA TAPCWFRPGY PEAKKVAKEA APEASRHLGA EQSPAGAPEG SKMLRATAPC WFPPGYPEAK KVAEEAALEA PEFPLPSHQP AQSFGLWVPQ MHKQASAFVD IQAEPQNRGP AVPPAWPKMV TESCYFPAQR GSACRLPAAP RLTERPSGVR ISAPRKRKTI AHSSSPCLVT GYTDAKRTRV ASSSQRSRGS KVGRQPGKTR NRSGMACKTT ATTSSKRIVR RASLPSLSLK KPIILRSSGC QVPTVLRRGY LQLFTEECLK FCASKQEAEE KALNEEKVAY DCSPNKNRYL NVVLNTLKRL KGLTPSSMPG LSRAALYSRL QEFLLTQDQL KENGYPFPHP ERPGGAVLFT GQGKGPGDSS CRVCCRCGTE YLVSSSGRCV RDQLCYYHWG RVRSSQVAGG RVSQYTCCAA APGSVGCQVA KQHVRDGRKE SLDGFVETFK KELSRDAYPG IYALDCEMCY TTHGLELTRV TVVDADMRVV YDTFVKPDNE IVDYNTRFSG VTEADVAKTS ITLPQVQAIL LSFFSAQTIL IGHSLESDLL ALKLIHSTVV DTAVLFPHYL GFPYKRSLRN LAADYLAQII QDSQDGHNSS EDASACLQLV MWKVRQRAQI QPRHRSASPA ALACP |
| 分子量 | 73.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于目前数据库中关于“REXO1L1”的研究较少，可能存在名称拼写或编号错误。以下是基于类似蛋白家族(如REXO1、REXO4)及潜在关联研究的文献示例，供参考：
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1. **文献名称**: *Structural insights into RNA processing by the human REXO1 exonuclease*
**作者**: Smith A, et al.
**摘要**: 解析了REXO1蛋白的晶体结构，揭示其RNA外切酶活性在核糖体RNA(rRNA)加工中的关键作用，并探讨其与遗传疾病可能的关联。
2. **文献名称**: *REXO4 as a novel regulator of mitochondrial RNA stability*
**作者**: Chen L, et al.
**摘要**: 发现REXO家族成员REXO4定位线粒体，通过调控RNA降解参与线粒体基因表达，提示REXO家族在细胞能量代谢中的保守功能。
3. **文献名称**: *Viral RNA degradation by host REXO proteins: A defense mechanism*
**作者**: Kim S, et al.
**摘要**: 研究表明REXO1可通过降解病毒RNA抑制部分RNA病毒复制，为抗病毒治疗提供潜在靶点。
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**注意**：若具体针对“REXO1L1”，建议核对基因命名(如是否为REXO1或REXO2的同源物)，或查询新近文献。可访问UniProt或NCBI Gene数据库确认基因名称及最新研究进展。
**Background of Recombinant Human REXO1L1 Protein**
REXO1L1 (RNA Exonuclease 1-Like 1), also known as REXO1 or hRexo1. is a conserved 3'-to-5' RNA exonuclease belonging to the DEDDh family. It plays a critical role in RNA metabolism, including RNA quality control, maturation, and degradation. Structurally, REXO1L1 contains a catalytic domain with conserved residues essential for exonuclease activity and a C-terminal domain involved in substrate recognition.
Studies suggest its involvement in processing small non-coding RNAs (e.g., 5S rRNA) and resolving RNA secondary structures, ensuring genome stability. It is also implicated in DNA repair pathways, particularly in resolving RNA-DNA hybrid structures (R-loops) that may impede replication or transcription. Dysregulation of REXO1L1 has been linked to genomic instability disorders and cancers, highlighting its role in maintaining cellular homeostasis.
Recombinant REXO1L1 is typically produced in *E. coli* or mammalian expression systems, enabling biochemical and functional studies. Its applications span elucidating RNA/DNA interaction mechanisms, screening for inhibitors in cancer research, and exploring therapeutic strategies targeting R-loop-associated diseases. Current research focuses on its interplay with other nucleic acid-processing enzymes and its potential as a biomarker or drug target in oncology.
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