| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SAMD10 |
| Uniprot No | Q9BYL1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-202 aa |
| 活性数据 | MFTELRSKLS PPRGRAGAVR AGFGERRDVD ATAHFSFCRT LLEHTVSAES IPCHLPRTPG TSLTWHDSRS QRAASSRPIK LLQQPGTDTP QGRLYSDHYG LYHTSPSLGG LTRPVVLWSQ QDVCKWLKKH CPHNYLVYVE AFSQHAITGR ALLRLNAEKL QRMGLAQEAQ RQEVLQQVLR LQVREEGRSL QLLSQASFGK MS |
| 分子量 | 22.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是可能与重组人SAMD10蛋白相关的示例性参考文献(请注意部分信息为推测性描述，建议通过学术数据库验证具体文献)：
1. **标题**: *"SAMD10 regulates type I interferon signaling through interaction with STAT1"*
**作者**: Liu Y, et al.
**摘要**: 该研究鉴定SAMD10为干扰素信号通路中的新型调控因子，通过重组蛋白实验表明其与STAT1结合，调节免疫相关基因表达。
2. **标题**: *"Crystal structure of human SAMD10 reveals a conserved SAM domain fold"*
**作者**: Tanaka K, et al.
**摘要**: 解析了重组人SAMD10蛋白的晶体结构，证实其具有典型SAM结构域特征，为功能研究提供结构基础。
3. **标题**: *"SAMD10 modulates oxidative stress response in macrophages via NF-κB pathway"*
**作者**: Chen H, et al.
**摘要**: 发现SAMD10在巨噬细胞中通过调控NF-κB通路影响氧化应激反应，重组蛋白过表达实验显示其抗炎作用。
4. **标题**: *"Expression and functional analysis of SAMD10 in hematopoietic stem cells"*
**作者**: Wang X, et al.
**摘要**: 利用重组SAMD10蛋白探究其对造血干细胞分化的影响，提示其在血液系统疾病中的潜在作用。
**注意**：以上文献为模拟示例，实际研究中请通过PubMed、Google Scholar等平台以**“SAMD10”**或**“SAMD family protein function”**等关键词检索近期文献，重点关注其与信号转导、免疫调控或疾病关联的研究方向。
SAMD10 (Sterile Alpha Motif Domain-containing protein 10) is a member of the SAM domain-containing protein family, characterized by a conserved ~70 amino acid SAM domain involved in protein-protein interactions and cellular signaling. In humans, SAMD10 is encoded by the *SAMD10* gene on chromosome 20 and is expressed in various tissues, particularly immune cells. It plays a role in modulating intracellular signaling pathways, including those regulating apoptosis, inflammation, and immune responses.
Though less studied than other SAMD proteins, emerging evidence links SAMD10 to immune regulation. It interacts with components of the TGF-β signaling pathway and may influence T-cell activation and cytokine production. SAMD10 has also been implicated in cancer biology, with altered expression observed in certain malignancies, suggesting potential involvement in tumor suppression or progression.
Recombinant human SAMD10 protein is typically produced in *E. coli* or mammalian expression systems for functional studies. Its purification enables exploration of its structural properties, binding partners, and mechanistic roles in cellular processes. Current research focuses on clarifying its physiological functions and therapeutic potential in immune disorders, cancer, and inflammatory diseases. Further studies are needed to fully characterize its interactome and signaling crosstalk in health and disease.
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