| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SEC22C |
| Uniprot No | Q9BRL7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-303 aa |
| 活性数据 | MSVIFFACVVRVRDGLPLSASTDFYHTQDFLEWRRRLKSLALRLAQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMAFCFLETLWWEFTASYDTTCIGLASRPYAFLEFDSIIQKVKWHFNYVSSSQMECSLEKIQEELKLQPPAVLTLEDTDVANGVMNGHTPMHLEPAPNFRMEPVTALGILSLILNIMCAALNLIRGVHLAEHSLQVAHEEIGNILAFLVPFVACIFQCYLYLFYSPARTMKVVLMLLFICLGNMYLHGLRNLWQILFHIGVAFLSSYQILTRQLQEKQSDCGV |
| 分子量 | 60.7 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SEC22C蛋白的3篇示例文献(注：以下内容为假设性示例，实际文献需通过学术数据库查询)：
1. **文献名称**：*"Structural Insights into the SEC22C Protein and Its Role in SNARE Complex Assembly"*
**作者**：Chen, L., et al.
**摘要**：该研究解析了SEC22C的晶体结构，揭示了其N端结构域与特定SNARE蛋白(如Syntaxin-5)的互作机制，表明SEC22C在内质网-高尔基体囊泡运输中的关键作用。
2. **文献名称**：*"SEC22C Modulates Exosome Secretion in Cancer Cells via Regulating Vesicle Trafficking"*
**作者**：Wang, Y., et al.
**摘要**：通过敲低实验发现，SEC22C缺失会显著抑制癌细胞外泌体的分泌，并降低肿瘤微环境中促转移因子的释放，提示其作为癌症治疗潜在靶点。
3. **文献名称**：*"Dysregulation of SEC22C in Neurodegenerative Disorders Linked to Autophagic Flux Impairment"*
**作者**：Kim, S., et al.
**摘要**：研究证明，SEC22C与自噬体膜融合相关，其表达异常会导致阿尔茨海默病模型中tau蛋白的异常聚集，表明其参与神经退行性疾病的病理机制。
如需真实文献，建议在PubMed或Web of Science中以“SEC22C”或“SEC22C AND (SNARE/membrane trafficking/cancer)”检索获取。
SEC22C, a member of the SEC22 vesicle trafficking protein family, plays a critical role in intracellular membrane transport processes. Belonging to the SEC22 subfamily of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins, it facilitates vesicle docking and fusion between donor and target membranes, particularly in endoplasmic reticulum (ER)-to-Golgi trafficking. Unlike its paralogs SEC22A and SEC22B, which are widely studied in COPII-mediated secretion and immune regulation, SEC22C exhibits distinct functional characteristics, though its precise mechanisms remain less defined.
The human SEC22C gene encodes a protein containing a conserved N-terminal domain and a C-terminal transmembrane anchor. As a recombinant protein, SEC22C is typically expressed in heterologous systems (e.g., E. coli or mammalian cells) for structural and functional studies. Research suggests its involvement in autophagy, secretory pathways, and cellular stress responses. Dysregulation of SEC22C has been tentatively linked to cancers and neurodegenerative disorders, though direct evidence is limited.
Current studies focus on its interactions with other SNAREs (e.g., syntaxins), potential roles in non-canonical trafficking, and tissue-specific expression patterns. Recombinant SEC22C serves as a tool to dissect membrane dynamics and develop therapies targeting vesicular transport defects. Further exploration of its isoform-specific functions could unveil novel pathways in cellular logistics and disease pathogenesis.
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