| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SEZ6L2 |
| Uniprot No | Q6UXD5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-809 aa |
| 活性数据 | MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI |
| 分子量 | 113.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SEZ6L2蛋白的虚构参考文献示例(仅供格式参考，实际文献需通过学术数据库检索)：
1. **文献名称**：*SEZ6L2蛋白在阿尔茨海默病中的潜在生物标志物作用*
**作者**：Smith A, et al.
**摘要**：研究证实重组SEZ6L2蛋白在阿尔茨海默病患者脑脊液中异常表达，可能通过调节β-淀粉样蛋白沉积参与疾病进程。
2. **文献名称**：*重组人SEZ6L2蛋白的哺乳动物表达系统优化及功能验证*
**作者**：Zhang Y, et al.
**摘要**：作者利用HEK293细胞高效表达重组SEZ6L2蛋白，验证其与神经突触粘附因子的相互作用，表明其可能在神经元发育中发挥作用。
3. **文献名称**：*SEZ6L2在肺癌转移中的调控机制*
**作者**：Tanaka K, et al.
**摘要**：通过体外实验发现，重组SEZ6L2蛋白可激活EGFR信号通路，促进肺癌细胞侵袭迁移，提示其作为治疗靶点的潜力。
4. **文献名称**：*SEZ6L2胞外结构域的晶体结构与功能分析*
**作者**：Johnson R, et al.
**摘要**：解析了重组SEZ6L2蛋白的胞外结构域晶体结构，揭示其与细胞表面受体结合的潜在机制，为药物设计提供基础。
**注意**：以上为模拟内容，实际文献请通过PubMed、Web of Science等平台检索关键词“SEZ6L2 recombinant protein”或“SEZ6L2 function”获取。
**Background of Seizure-Related Protein 6 Homolog-Like 2 (SEZ6L2)**
SEZ6L2. a member of the SEZ6 protein family, is a transmembrane or secreted glycoprotein implicated in neuronal development, synaptic function, and cell adhesion. Structurally, it contains conserved MAM (meprin/A5 antigen/PTPmu) and CUB (complement C1r/C1s) domains, which are associated with protein-protein interactions and extracellular matrix binding. Initially identified through its homology to SEZ6. a protein linked to seizure susceptibility, SEZ6L2 is broadly expressed in the brain, particularly in neurons, and enriched in synaptic regions, suggesting roles in neurodevelopment and synaptic plasticity.
Emerging studies highlight its potential involvement in neurological and oncological contexts. In Alzheimer’s disease, SEZ6L2 is reported to interact with amyloid-beta precursor protein (APP), influencing amyloidogenic processing. It is also upregulated in certain cancers, such as breast and colorectal cancer, where it may promote tumor progression via mechanisms involving cell migration and survival pathways. Additionally, SEZ6L2 has been proposed as a biomarker due to its aberrant expression in disease states. Despite these associations, its precise molecular mechanisms and physiological functions remain partially undefined, warranting further exploration into its therapeutic or diagnostic potential. Research continues to unravel its dual roles in both health and disease, bridging neuroscience and oncology.
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