| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SS18L1 |
| Uniprot No | O75177 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-396aa |
| 活性数据 | MSVAFASARP RGKGEVTQQT IQKMLDENHH LIQCILEYQS KGKTAECTQY QQILHRNLVY LATIADSNQN MQSLLPAPPT QNMNLGPGAL TQSGSSQGLH SQGSLSDAIS TGLPPSSLLQ GQIGNGPSHV SMQQTAPNTL PTTSMSISGP GYSHAGPASQ GVPMQGQGTI GNYVSRTNIN MQSNPVSMMQ QQAATSHYSS AQGGSQHYQG QSSIAMMGQG SQGSSMMGQR PMAPYRPSQQ GSSQQYLGQE EYYGEQYSHS QGAAEPMGQQ YYPDGHGDYA YQQSSYTEQS YDRSFEESTQ HYYEGGNSQY SQQQAGYQQG AAQQQTYSQQ QYPSQQSYPG QQQGYGSAQG APSQYPGYQQ GQGQQYGSYR APQTAPSAQQ QRPYGYEQGQ YGNYQQ |
| 分子量 | 42.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为基于重组人SS18L1蛋白相关研究的模拟参考文献示例，供参考(实际文献需通过学术数据库核实)：
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1. **标题**: *SS18L1 interacts with the SWI/SNF chromatin remodeling complex in synovial sarcoma pathogenesis*
**作者**: Jones M, et al.
**摘要**: 研究通过重组表达人SS18L1蛋白，发现其与SWI/SNF复合物亚基相互作用，促进滑膜肉瘤中染色体重塑异常及致癌表型。
2. **标题**: *Recombinant SS18L1 protein triggers oncogenic fusion-like transcriptional programs in vitro*
**作者**: Smith KL, et al.
**摘要**: 利用重组SS18L1蛋白进行体外实验，揭示其通过异常激活转录因子(如SOX2)驱动细胞恶性转化，与SS18-SSX融合蛋白功能部分重叠。
3. **标题**: *Structural insights into SS18L1’s role in neuronal development via X-ray crystallography*
**作者**: Tanaka R, et al.
**摘要**: 解析重组人SS18L1蛋白晶体结构，发现其N端结构域介导与核转运蛋白的结合，为研究其在神经发育中的作用提供分子基础。
4. **标题**: *SS18L1 loss alters DNA damage response in breast cancer cells*
**作者**: Lee S, et al.
**摘要**: 通过重组蛋白回补实验，证明SS18L1缺失导致乳腺癌细胞基因组不稳定性，其功能依赖与BRCA1的相互作用。
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**说明**：以上文献为假设示例，实际研究中建议通过PubMed、Google Scholar等平台以关键词“recombinant SS18L1”、“SS18L1 protein function”查询，并关注其与肿瘤、染色质调控或信号通路相关的研究。
SS18L1 (SS18 Like Protein 1), also known as SSXT or C18orf1. is a nuclear protein belonging to the SS18 family. It shares structural homology with SS18. a transcriptional regulator involved in chromatin remodeling complexes. SS18L1 contains conserved domains, including an N-terminal SNH (SYT N-terminal homology) domain and a C-terminal SSRD (SYT/SSX repeat domain), which facilitate protein-protein interactions and chromatin association.
Functionally, SS18L1 plays roles in transcriptional regulation and chromatin dynamics by interacting with components of the SWI/SNF chromatin-remodeling complex, such as BRG1. It has been implicated in neural development, cellular differentiation, and synapse function. Aberrant SS18L1 expression or fusion events are linked to human diseases. Notably, chromosomal translocations involving SS18L1 (e.g., SS18L1-SSX1 fusion) are rare but observed in synovial sarcomas, mirroring the pathogenic SS18-SSX fusions characteristic of these tumors. Additionally, SS18L1 mutations have been associated with neurological disorders and certain cancers.
Recombinant SS18L1 protein is widely used to study its biochemical properties, binding partners, and pathological mechanisms. Its applications include in vitro assays to characterize interactions with chromatin modifiers, functional studies in cancer models, and therapeutic target validation. Research on SS18L1 enhances understanding of its dual roles in development and disease, offering insights into targeted therapies for fusion-driven cancers.
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