| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TCEAL4 |
| Uniprot No | Q96EI5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-215 aa |
| 活性数据 | MEKLYSENEG MASNQGKMEN EEQPQDERKP EVTCTLEDKK LENEGKTENK GKTGDEEMLK DKGKPESEGE AKEGKSEREG ESEMEGGSER EGKPEIEGKP ESEGEPGSET RAAGKRPAED DVPRKAKRKT NKGLAHYLKE YKEAIHDMNF SNEDMIREFD NMAKVQDEKR KSKQKLGAFL WMQRNLQDPF YPRGPREFRG GCRAPRRDIE DIPYV |
| 分子量 | 24.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TCEAL4蛋白的3篇参考文献的示例(内容为模拟概括，仅供参考)：
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1. **文献名称**: *"TCEAL4 modulates MYC transcriptional activity through direct interaction in cancer cells"*
**作者**: Smith J., Brown K. et al. (2021)
**摘要**: 该研究发现TCEAL4作为转录调控因子，通过直接结合MYC蛋白抑制其转录活性，抑制肿瘤细胞增殖，并在卵巢癌细胞中验证了重组TCEAL4蛋白的过表达可诱导凋亡。
2. **文献名称**: *"Structural and functional characterization of recombinant human TCEAL4 as a nucleosome-binding protein"*
**作者**: Lee S., Wang H. et al. (2019)
**摘要**: 通过重组表达纯化TCEAL4蛋白，结合X射线晶体学分析其结构，发现其C末端结构域特异识别核小体，可能通过表观遗传调控影响基因沉默，为肿瘤治疗提供新靶点。
3. **文献名称**: *"TCEAL4 downregulation promotes Wnt/β-catenin signaling in epithelial ovarian cancer"*
**作者**: Zhang Y., Chen L. et al. (2020)
**摘要**: 研究显示，TCEAL4通过抑制Wnt通路关键蛋白β-catenin的核转运，抑制卵巢癌侵袭。重组TCEAL4蛋白的体外实验证实其可逆转癌细胞上皮-间质转化(EMT)。
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**注意**：上述文献为示例，实际研究中请通过PubMed或Web of Science等平台检索最新发表的相关论文。若需真实文献线索，可查找关于TCEAL4在转录调控、癌症(尤其是卵巢癌)及表观遗传机制中的研究。
TCEAL4 (Transcription Elongation Factor A (SII)-Like 4) is a member of the TCEAL family, a group of evolutionarily conserved nuclear proteins implicated in transcriptional regulation and chromatin remodeling. This protein contains a conserved TEA/ATTS DNA-binding domain, enabling interactions with specific promoter regions or transcriptional machinery. Encoded by a gene located on human chromosome Xq22.1. TCEAL4 is ubiquitously expressed but shows elevated levels in reproductive tissues and the central nervous system.
Functionally, TCEAL4 acts as a putative transcriptional regulator, modulating the activity of oncogenes or tumor suppressors. Studies suggest its role in tumorigenesis, with evidence linking reduced TCEAL4 expression to ovarian cancer progression, where it may act as a tumor suppressor by inhibiting proliferation and migration. Conversely, it has been associated with enhanced chemoresistance in breast cancer, highlighting context-dependent roles. Additionally, TCEAL4 is implicated in neuronal development and neurodegenerative disorders, though mechanisms remain unclear.
Recombinant TCEAL4 protein, engineered via heterologous expression systems (e.g., E. coli, mammalian cells), retains post-translational modifications critical for functional studies. It is widely used to investigate protein-DNA/RNA interactions, signaling pathways (e.g., Wnt/β-catenin), and therapeutic targeting strategies. Despite advances, its precise molecular partners and regulatory networks require further elucidation.
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