| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TCEAL6 |
| Uniprot No | Q6IPX3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-200 aa |
| 活性数据 | MEKPYNKNEG NLENEGKPED EVEPDDEGKS DEEEKPDAEG KTECEGKRKA EGEPGDEGQL EDKGSQEKQG KSEGEGKPQG EGKPASQAKP EGQPRAAEKR PAGDYVPRKA KRKTDRGTDD SPKDSQEDLQ ERHLSSEEMM RECGDVSRAQ EELRKKQKMG GFHWMQRDVQ DPFAPRGQRG VRGVRGGGRG QRGLHDIPYL |
| 分子量 | 22.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TCEAL6蛋白的参考文献示例(注：部分信息为示例性概括，可能不完全对应真实文献)：
1. **"Recombinant TCEAL6 Expression Suppresses Ovarian Cancer Cell Proliferation"**
*Smith et al.*
摘要：研究通过大肠杆菌成功表达并纯化重组TCEAL6蛋白，发现其在卵巢癌细胞中过表达可抑制增殖并诱导凋亡，提示其可能作为抑癌因子发挥作用。
2. **"Structural Insights into TCEAL6 Reveal a Novel Transcriptional Regulatory Domain"**
*Johnson & Lee*
摘要：通过X射线晶体学解析了重组TCEAL6的三维结构，发现其包含一个保守的转录调控结构域，可能与DNA结合或蛋白互作相关，为功能机制提供结构基础。
3. **"TCEAL6 Modulates MYC-Mediated Transcription in Cancer Cells"**
*Chen et al.*
摘要：研究利用重组TCEAL6蛋白进行体外互作实验，证明其通过抑制MYC转录活性调控下游靶基因，在乳腺癌中低表达与MYC通路异常激活及患者不良预后相关。
4. **"TCEAL6 as a Biomarker in Serous Ovarian Carcinoma"**
*Wang et al.*
摘要：通过免疫组化分析发现，TCEAL6在高级别浆液性卵巢癌组织中表达显著下调，重组蛋白功能实验表明其通过调控细胞周期蛋白抑制肿瘤进展。
**提示**：以上为示例性内容，实际文献需通过PubMed、Web of Science等数据库查询关键词“TCEAL6”、“recombinant TCEAL6 protein”获取。研究多聚焦于TCEAL6在癌症中的转录调控功能及潜在治疗意义。
**Background of Recombinant Human TCEAL6 Protein**
The TCEAL6 (Transcription Elongation Factor A (SII)-Like 6) protein is a member of the TCEAL family, which comprises nuclear factors involved in transcriptional regulation and cellular processes. TCEAL6 is encoded by a gene located on the X chromosome (Xq22.1) and is characterized by a conserved TEA DNA-binding domain, suggesting its role in modulating gene expression. Structurally, it functions as a transcription regulator, potentially interacting with E-box-binding proteins like c-Myc to influence downstream target genes.
Studies indicate TCEAL6 participates in pathways related to cell proliferation, apoptosis, and differentiation. Its dysregulation has been linked to cancers, particularly ovarian cancer, where it may act as a tumor suppressor by inhibiting oncogenic signaling. Recombinant human TCEAL6 protein, produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), retains biological activity and is widely utilized for *in vitro* studies to elucidate its molecular mechanisms, protein interactions, and therapeutic potential. Its applications span functional assays, antibody development, and mechanistic exploration of transcriptional networks in health and disease. Further research is needed to fully unravel its physiological and pathological roles.
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