关键信息
-
基因名
GPR56
- 应用
-
别名
GPR56；GPR56；TM7LN4；TM7XN1；Adhesion G-Protein coupled receptor G1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9Y653
-
表达区间
1-693aa
-
氨基酸序列
MTPQSLLQTTLFLLSLLFLVQGAHGRGHREDFRFCSQRNQTHRSSLHYKPTPDLRISIENSEEALTVHAPFPAAHPASRSFPDPRGLYHFCLYWNRHAGRLHLLYGKRDFLLSDKASSLLCFQHQEESLAQGPPLLATSVTSWWSPQNISLPSAASFTFSFHSPPHTAAHNASVDMCELKRDLQLLSQFLKHPQKASRRPSAAPASQQLQSLESKLTSVRFMGDMVSFEEDRINATVWKLQPTAGLQDLHIHSRQEEEQSEIMEYSVLLPRTLFQRTKGRSGEAEKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVANLTEPVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPGHWSSAGCETVRRETQTSCFCNHLTYFAVLMVSSVEVDAVHKHYLSLLSYVGCVVSALACLVTIAAYLCSRVPLPCRRKPRDYTIKVHMNLLLAVFLLDTSFLLSEPVALTGSEAGCRASAIFLHFSLLTCLSWMGLEGYNLYRLVVEVFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDVDNYGPIILAVHRTPEGVIYPSMCWIRDSLVSYITNLGLFSLVFLFNMAMLATMVVQILRLRPHTQKWSHVLTLLGLSLVLGLPWALIFFSFASGTFQLVVLYLFSIITSFQGFLIFIWYWSMRLQARGGPSPLKSNSDSARLPISSGSTSSSRI
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GPR56, also known as ADGRG1, is a member of the adhesion G protein-coupled receptor (GPCR) family that has garnered attention due to its significant roles in various physiological and pathological processes. This receptor is particularly noted for its involvement in brain development and function, as mutations in the GPR56 gene have been linked to neurological disorders such as bilateral frontoparietal polymicrogyria, a condition characterized by abnormal brain folds. Research indicates that GPR56 plays a critical role in cell adhesion, migration, and communication, specifically in neural and vascular contexts. Through its unique structure, GPR56 interacts with extracellular matrix proteins, influencing cellular behavior and tissue organization. Furthermore, studies suggest that GPR56 may be implicated in various cancers, where its expression levels can affect tumor progression and metastasis. The recombinant GPR56 protein is thus a valuable tool for exploring these functions and mechanisms in detail. By characterizing its structure and signaling pathways, researchers aim to elucidate how GPR56 contributes to neural development and tumor biology, paving the way for potential therapeutic interventions targeting GPR56-related diseases. Understanding the functional implications of GPR56 through its recombinant protein can provide insights into the broader context of GPCR signaling and its translational potential in regenerative medicine and oncology.
