| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF131 |
| Uniprot No | P52739 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-623 aa |
| 活性数据 | MEAEETMECLQEFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFY KFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKA LEVRNKENSAPLEENTTGKNEAKKRKIAETSNVITESLPSAESEPVEIEVEIAEGTIEVE DEGIETLEEVASAKQSVKYIQSTGSSDDSALALLADITSKYRQGDRKGQIKEDGCPSDPT SKQVEGIEIVELQLSHVKDLFHCEKCNRSFKLFYHFKEHMKSHSTESFKCEICNKRYLRE SAWKQHLNCYHLEEGGVSKKQRTGKKIHVCQYCEKQFDHFGHFKEHLRKHTGEKPFECPN CHERFARNSTLKCHLTACQTGVGAKKGRKKLYECQVCNSVFNSWDQFKDHLVIHTGDKPN HCTLCDLWFMQGNELRRHLSDAHNISERLVTEEVLSVETRVQTEPVTSMTIIEQVGKVHV LPLLQVQVDSAQVTVEQVHPDLLQDSQVHDSHMSELPEQVQVSYLEVGRIQTEEGTEVHV EELHVERVNQMPVEVQTELLEADLDHVTPEIMNQEERESSQADAAEAAREDHEDAEDLET KPTVDSEAEKAENEDRTALPVLE |
| 分子量 | 71.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **"ZNF131 is a novel oncogene in papillary thyroid carcinoma"**
*Authors: Zhang Y et al.*
摘要：研究发现ZNF131在甲状腺乳头状癌中高表达，通过调控Wnt/β-catenin通路促进肿瘤增殖和转移，提示其作为治疗靶点的潜力。
2. **"Zinc finger protein 163 (ZNF131) interacts with p53 to regulate DNA repair"**
*Authors: Lee S, Kim JH*
摘要：证实ZNF131与p53蛋白直接互作，影响DNA损伤修复机制，在细胞周期调控及基因组稳定性中起关键作用。
3. **"Recombinant expression and functional characterization of human ZNF131"**
*Authors: Müller R et al.*
摘要：成功在大肠杆菌中重组表达ZNF131蛋白，并验证其通过锌指结构域结合特定DNA序列，为后续功能研究提供工具。
4. **"ZNF131 promotes hepatocellular carcinoma progression through epigenetic silencing of CDKN1A"**
*Authors: Wang Q et al.*
摘要：揭示ZNF131通过招募组蛋白甲基转移酶抑制抑癌基因CDKN1A表达，驱动肝癌发展，强调其表观遗传调控功能。
ZNF131. a member of the zinc finger protein family, functions as a transcriptional regulator involved in diverse cellular processes. Encoded by the ZNF131 gene located on human chromosome 5 (5q21.3), it contains an N-terminal SCAN domain and multiple C-terminal C2H2-type zinc finger motifs, enabling DNA binding and protein-protein interactions. As a Krüppel-associated box (KRAB) domain-containing protein, it likely recruits chromatin-modifying complexes to mediate gene silencing. Studies suggest its role in embryonic development, cell differentiation, and tumorigenesis. In colon cancer, ZNF131 is reported to promote proliferation by modulating Wnt/β-catenin signaling. Its recombinant form (rZNF131) enables functional studies to decipher molecular mechanisms, potential therapeutic targets, and diagnostic biomarkers. Despite progress, its precise physiological functions and regulatory networks remain under investigation, necessitating further research to clarify its tissue-specific roles and disease associations. (UniProt/Swiss-Prot entry: Q9ULJ6)
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