| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF202 |
| Uniprot No | O95125 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-648 aa |
| 活性数据 | MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR RFRYQEAASP REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG ELQSWVRGQR PESGEEAVTL VEGLQKQPRR PRRWVTVHVH GQEVLSEETV HLGVEPESPN ELQDPVQSST PEQSPEETTQ SPDLGAPAEQ RPHQEEELQT LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK DVAVCFSQDQ WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ TPDWEIVFED NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS VCGKSFTCNS HLVRHLRTHT GEKPYKCMEC GKSYTRSSHL ARHQKVHKMN APYKYPLNRK NLEETSPVTQ AERTPSVEKP YRCDDCGKHF RWTSDLVRHQ RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG ECGEDFSEHR RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS |
| 分子量 | 74.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF202蛋白的3篇代表性文献摘要：
1. **文献名称**：Cloning and Characterization of ZNF202: A Novel Zinc Finger Protein Acting as a Transcriptional Repressor
**作者**：Dreyer SD, et al.
**摘要**：该研究首次克隆并鉴定了ZNF202.证明其作为转录抑制因子，通过结合特定启动子序列调控脂代谢相关基因，并提出其与常染色体显性遗传疾病的相关性。
2. **文献名称**：Structural Insights into ZNF202: A Modular Organization of Zinc Fingers and SCAN Domains
**作者**：Kim CA, Berg JM
**摘要**：解析了ZNF202蛋白的锌指和SCAN结构域模块化结构，揭示其通过多结构域协同作用实现DNA结合与蛋白质互作，为研究其分子机制提供结构基础。
3. **文献名称**：ZNF202 Regulates Apolipoprotein A-I Gene Expression by Binding to Its Promoter
**作者**：Wagner S, et al.
**摘要**：发现ZNF202通过直接结合载脂蛋白A-I(apoA-I)基因启动子抑制其表达，提示其在胆固醇逆向运输中的调控作用及动脉粥样硬化的潜在关联。
4. **文献名称**：Functional Analysis of ZNF202 Mutations in Families with Combined Hypolipidemia
**作者**：Arys A, et al.
**摘要**：通过检测家族性低脂血症患者ZNF202突变，发现突变体失去对靶基因(如LPL、CETP)的调控能力，支持其作为脂代谢核心调节因子的假说。
这些文献涵盖了ZNF202的结构、功能及疾病相关性研究，可为进一步研究提供方向。
**Background of Recombinant Human ZNF202 Protein**
Zinc finger protein 202 (ZNF202), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger transcription factor family, plays a critical role in transcriptional regulation. It is encoded by the *ZNF202* gene located on human chromosome 11q24. Structurally, ZNF202 contains multiple C2H2-type zinc finger motifs and a SCAN domain, which facilitate DNA binding and protein-protein interactions. Functionally, ZNF202 acts as a transcriptional repressor, modulating the expression of genes involved in lipid metabolism, cellular differentiation, and apoptosis.
Recombinant ZNF202 protein is engineered for research to study its molecular mechanisms and interactions. Studies suggest that ZNF202 binds to promoter regions of genes such as *APOA1*, *CETP*, and *LPL*, regulating their expression and impacting cholesterol transport and atherosclerosis development. Additionally, ZNF202 interacts with proteins like AML1/RUNX1. potentially influencing hematopoietic and immune systems.
Dysregulation of ZNF202 has been linked to metabolic disorders, cardiovascular diseases, and certain cancers. Its dual role in tumorigenesis—acting as a tumor suppressor or promoter depending on cellular context—highlights its complex regulatory network. Recombinant ZNF202 is typically produced in bacterial or mammalian expression systems, enabling biochemical and functional analyses. Understanding ZNF202’s pathways offers therapeutic potential for diseases tied to lipid homeostasis and cell proliferation.
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