关键信息
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基因名
SNRPB
- 应用
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别名
Small nuclear ribonucleoprotein-associated proteins B and B'. snRNP-B. Sm protein B/B'. Sm-B/B'. SmB/B'
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P14678
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表达区间
1-80 aa
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氨基酸序列
MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAEREEKRVLGLVLLRGENLVSM
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分子量
34.54 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The SNRPB (Small Nuclear Ribonucleoprotein B) protein is a crucial component of the spliceosome, a complex responsible for the post-transcriptional modification of precursor messenger RNA (pre-mRNA) in eukaryotic cells. It plays a vital role in the splicing process, where introns are removed and exons are joined to produce mature mRNA, which subsequently directs protein synthesis. Dysregulation of SNRPB expression or function is implicated in various diseases, including cancers and neurodegenerative disorders, making it an important target for research. Recent studies have focused on characterizing the structural and functional properties of SNRPB, as well as its interactions with other spliceosomal factors. Understanding the mechanistic role of SNRPB in pre-mRNA splicing and its regulatory pathways is essential for elucidating the molecular basis of splicing-related diseases. Moreover, the development of SNRPB recombinant proteins has facilitated the investigation of its function and interaction dynamics, providing insights that could lead to novel therapeutic strategies for conditions arising from splicing errors. This research area holds the promise of uncovering new molecular targets and enhancing our comprehension of gene expression regulation at the translational level.
