关键信息
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基因名
SPRR2E
- 应用
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别名
SPRR2E; Small proline-rich protein 2E; SPR-2E; Small proline-rich protein II; SPR-II
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22531
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表达区间
1-72aa
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氨基酸序列
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKCPPVTPS PPCQPKCPPK SK
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分子量
7.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SPRR2E, a member of the small proline-rich protein (SPRR) family, plays a crucial role in epithelial differentiation and barrier function. It is primarily expressed in keratinocytes and has been implicated in processes such as wound healing and skin homeostasis. Research has shown that SPRR2E contributes to the structural integrity of the epidermis by forming a part of the cornified cell envelope, which is essential for protecting underlying tissues from environmental insults. Over the years, studies have indicated that aberrations in SPRR2E expression may be associated with various dermatological conditions, including psoriasis and skin cancers, highlighting its potential as a biomarker for skin-related diseases. Recombinant SPRR2E protein studies are aimed at understanding its exact functional mechanisms, interactions with other skin barrier proteins, and potential therapeutic applications. By producing SPRR2E in a laboratory setting, researchers can investigate its biochemical properties and role in skin physiology in greater detail, paving the way for novel treatments and diagnostic tools for skin disorders. As the quest for targeted therapies continues, understanding the biology of SPRR2E becomes increasingly relevant, providing insights into not only skin health but also broader implications for epithelial tissue function.
