关键信息
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基因名
TAC3
- 应用
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别名
Gamma tachykinin 3; Neurokinin B; Neurokinin B like protein; Neurokinin B protein; Neurokinin beta; Neurokinin-B; NeurokininB; Neuromedin K; Neuromedin-K; NeuromedinK; NKB; NKNB ; Preprotachykinin B; PreprotachykininB; PRO 1155; PRO1155 ; TAC 3; TAC3; Tachykinin 3; Tachykinin3; TKNK_HUMAN; ZNEUROK 1; ZNEUROK1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHF0
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表达区间
81-90 aa
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氨基酸序列
DMHDFFVGLM
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分子量
13.4kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TAC3 (tachykinin-3) is a neuropeptide involved in various physiological processes, including the regulation of reproductive functions and energy homeostasis. Its role in the central nervous system has garnered attention, particularly in understanding its implications in reproduction and related disorders. The TAC3 gene encodes the neuropeptide neurokinin B (NKB), which acts on neurokinin receptors, primarily NK3R, influencing the release of gonadotropin-releasing hormone (GnRH) and playing a crucial role in the hypothalamic-pituitary-gonadal (HPG) axis. Dysregulation of TAC3 signaling has been linked to conditions such as hypogonadotropic hypogonadism, where diminished reproductive hormone levels may lead to infertility. Moreover, TAC3 is being investigated for its potential involvement in metabolic disorders, given its effects on energy balance and body weight regulation. The recombinant expression of TAC3 and its related peptides allows for the study of their structure-function relationships and therapeutic potentials. Advances in biotechnology, including the development of recombinant proteins, facilitate a deeper understanding of TAC3's mechanisms and open new avenues for potential therapeutic interventions for reproductive and metabolic health issues. Such research not only enhances our understanding of neuropeptide signaling pathways but also lays the groundwork for potential treatments for related disorders by exploring TAC3's role in both the central nervous system and peripheral physiological processes. Overall, the study of TAC3 recombinant protein is pivotal in elucidating the complex interplay of neuropeptides in human health and disease.
