关键信息
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基因名
WDR70
- 应用
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别名
4833422F06Rik; FLJ10233; MGC109151; RGD1309487; WD repeat containing Protein 70; WD repeat domain 70; WD repeat-containing Protein 70; wdr70; WDR70_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NW82
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表达区间
1-654 aa
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氨基酸序列
MERSGPSEVT GSDASGPDPQ LAVTMGFTGF GKKARTFDLE AMFEQTRRTA VERSRKTLEA REKEEEMNRE KELRRQNEDI EPTSSRSNVV RDCSKSSSRD TSSSESEQSS DSSDDELIGP PLPPKMVGKP VNFMEEDILG PLPPPLNEEE EEAEEEEEEE EEEENPVHKI PDSHEITLKH GTKTVSALGL DPSGARLVTG GYDYDVKFWD FAGMDASFKA FRSLQPCECH QIKSLQYSNT GDMILVVSGS SQAKVIDRDG FEVMECIKGD QYIVDMANTK GHTAMLHTGS WHPKIKGEFM TCSNDATVRT WEVENPKKQK SVFKPRTMQG KKVIPTTCTY SRDGNLIAAA CQNGSIQIWD RNLTVHPKFH YKQAHDSGTD TSCVTFSYDG NVLASRGGDD SLKLWDIRQF NKPLFSASGL PTMFPMTDCC FSPDDKLIVT GTSIQRGCGS GKLVFFERRT FQRVYEIDIT DASVVRCLWH PKLNQIMVGT GNGLAKVYYD PNKSQRGAKL CVVKTQRKAK QAETLTQDYI ITPHALPMFR EPRQRSTRKQ LEKDRLDPLK SHKPEPPVAG PGRGGRVGTH GGTLSSYIVK NIALDKTDDS NPREAILRHA KAAEDSPYWV SPAYSKTQPK TMFAQVESDD EEAKNEPEWK KRKI
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分子量
73.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
WDR70, a member of the WD40 repeat protein family, plays a critical role in various cellular processes, including RNA metabolism, protein folding, and cellular stress responses. Its structure, characterized by multiple WD repeats, facilitates interactions with a myriad of protein partners, suggesting a versatile function in signaling pathways and protein complexes. Research into WDR70 has gained momentum due to its implications in several diseases, including cancer and neurodegenerative disorders, where its expression levels and activity may influence cellular homeostasis and stress resilience. The reconstitution of WDR70 as a recombinant protein offers a valuable tool for elucidating its biochemical properties and interactions. By allowing for controlled studies in vitro, these recombinant proteins can help delineate the precise mechanisms by which WDR70 contributes to key cellular functions and its potential role in disease pathology. Furthermore, understanding the post-translational modifications and regulatory mechanisms governing WDR70 activity could reveal new therapeutic avenues for targeting its function in disease contexts. Overall, the study of WDR70 as a recombinant protein holds promise for advancing our understanding of its biological significance and the development of novel strategies for intervention in related diseases.
