关键信息
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基因名
DTX3L
- 应用
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别名
B-lymphoma- and BAL-associated protein;Protein deltex-3-like;RING-type E3 ubiquitin transferase DTX3L ;Rhysin-2 (Rhysin2)
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TDB6
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表达区间
1-740aa
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氨基酸序列
MASHLRPPSPLLVRVYKSGPRVRRKLESYFQSSKSSGGGECTVSTQEHEAPGTFRVEFSERAAKERVLKKGEHQILVDEKPVPIFLVPTENSIKKNTRPQISSLTQSQAETPSGDMHQHEGHIPNAVDSCLQKIFLTVTADLNCNLFSKEQRAYITTLCPSIRKMEGHDGIEKVCGDFQDIERIHQFLSEQFLESEQKQQFSPSMTERKPLSQQERDSCISPSEPETKAEQKSNYFEVPLPYFEYFKYICPDKINSIEKRFGVNIEIQESSPNMVCLDFTSSRSGDLEAARESFASEFQKNTEPLKQECVSLADSKQANKFKQELNHQFTKLLIKEKGGELTLLGTQDDISAAKQKISEAFVKIPVKLFAANYMMNVIEVDSAHYKLLETELLQEISEIEKRYDICSKVSEKGQKTCILFESKDRQVDLSVHAYASFIDAFQHASCQLMREVLLLKSLGKERKHLHQTKFADDFRKRHPNVHFVLNQESMTLTGLPNHLAKAKQYVLKGGGMSSLAGKKLKEGHETPMDIDSDDSKAASPPLKGSVSSEASELDKKEKGICVICMDTISNKKVLPKCKHEFCAPCINKAMSYKPICPTCQTSYGIQKGNQPEGSMVFTVSRDSLPGYESFGTIVITYSMKAGIQTEEHPNPGKRYPGIQRTAYLPDNKEGRKVLKLLYRAFDQKLIFTVGYSRVLGVSDVITWNDIHHKTSRFGGPEMYGYPDPSYLKRVKEELKAKGIE
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分子量
107.03 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
DTX3L (Deltex Drosophila homolog 3-like) is an E3 ubiquitin ligase that plays a crucial role in cellular processes such as signal transduction, cell differentiation, and immune response. Emerging evidence suggests that DTX3L is involved in the regulation of various oncogenic pathways and has implications in cancer biology. Research has shown that DTX3L may modulate the Notch signaling pathway, which is essential for cell fate determination during embryonic development and is often dysregulated in cancers. Additionally, DTX3L has been linked to the maturation of immune cells, highlighting its potential role in immunological disorders. The study of DTX3L and its recombinant protein is particularly important for understanding its functional mechanisms and therapeutic potential. Recombinant DTX3L protein can be utilized in functional assays to elucidate its interactions with substrates and signaling pathways. Such studies could pave the way for the development of novel strategies to target DTX3L in cancer and other diseases, offering insights that could lead to effective therapeutic approaches. Overall, the investigation of DTX3L and its recombinant protein contributes significantly to the field of molecular biology and has potential implications in clinical research, especially concerning tumor biology and immune regulation.
