关键信息
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基因名
LRP-1 Cluster IV
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简介
LRP-1 Cluster IV Protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster IV Protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster IV Protein, Human (CHO, His) is the recombinant human-derived LRP-1 Cluster IV protein, expressed by CHO , with C-10*His labeled tag.
- 应用
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别名
LRP1 Cluster IV; LRP-1 Cluster IV
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种属
Human
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表达系统
CHO
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q07954-1
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表达区间
S3332-D3779
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蛋白长度
Partial
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分子量
60-88 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
LRP-1 (Low-Density Lipoprotein Receptor-Related Protein 1) is a key receptor involved in various physiological processes, including lipid metabolism, cell signaling, and the clearance of extracellular matrix components. Cluster IV of LRP-1 specifically refers to a group of receptor variants that play crucial roles in neurological health and disease, particularly in the context of neurodegenerative disorders such as Alzheimer's disease. The study of LRP-1 Cluster IV recombinant proteins is pivotal as it helps elucidate the receptor’s functional domains and mechanisms of action. Researchers are particularly interested in understanding how these variations influence the receptor's ability to bind ligands (such as apolipoproteins and proteases) and mediate cellular uptake, which could reveal new therapeutic targets. Additionally, investigating the structural and functional characteristics of LRP-1 Cluster IV helps in deciphering its role in synaptic plasticity and neuronal survival, contributing to the overall understanding of brain health. Recombinant protein studies allow for detailed exploration of this receptor's interaction with other cellular pathways, providing insights that could lead to novel interventions in treating diseases characterized by dysfunctional lipid metabolism or impaired neuronal function. The findings from this research may also contribute to the development of biomarkers for early diagnosis and prognosis in neurodegenerative conditions. Thus, LRP-1 Cluster IV recombinant proteins represent an important avenue of research with potential implications for therapeutic strategies in brain-related diseases.
