关键信息
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基因名
FGFR-1 alpha (IIIc)
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简介
FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag.
- 应用
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别名
FGF R1a; FGFR1 alpha
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11362-7
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表达区间
R22-E374
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蛋白长度
Extracellular Domain
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分子量
65-90 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
FGFR-1 alpha (IIIc) is a member of the fibroblast growth factor receptor (FGFR) family, which plays a crucial role in various biological processes such as cell proliferation, differentiation, and survival. Research into FGFR-1 has gained momentum due to its involvement in several pathological conditions, including cancer, where aberrant signaling pathways contribute to tumor growth and metastasis. The FGFR-1 alpha (IIIc) isoform is particularly interesting because of its unique extracellular domain, which allows for specific interactions with various fibroblast growth factors. This isoform is also implicated in developmental processes and tissue homeostasis, making it a potential target for therapeutic interventions. The development of recombinant FGFR-1 alpha (IIIc) proteins enables detailed studies of its biological functions and interactions. By understanding the structure and activity of this receptor, researchers aim to elucidate its role in normal physiology and disease states, paving the way for the design of novel drugs that can inhibit FGFR signaling in cancers where this pathway is overactive. Furthermore, FGFR inhibitors are being explored as treatment options for various tumors, underscoring the importance of FGFR-1 alpha (IIIc) research in the context of targeted therapies. Overall, the investigation of this specific FGFR isoform holds promise for advancing our understanding of growth factor signaling and developing innovative strategies to combat FGFR-associated diseases.
