Recombinant Human FAM110B protein

**Background on FAM110B Recombinant Protein**

FAM110B (Family with sequence similarity 110 member B) is a protein-coding gene located on human chromosome 9. with limited functional characterization in current literature. It belongs to the FAM110 family, which includes proteins with conserved domains potentially involved in cell cycle regulation, though their exact mechanisms remain unclear. FAM110B is hypothesized to play roles in cellular processes such as mitosis, cytoskeletal organization, or signal transduction, supported by its interaction with microtubule-associated proteins and its nuclear-cytoplasmic localization. Dysregulation of FAM110B has been loosely associated with cancers, including gliomas and prostate cancer, though its oncogenic or tumor-suppressive role requires further validation.

Recombinant FAM110B protein is produced using heterologous expression systems (e.g., *E. coli*, mammalian cells) to enable functional studies. The protein is typically engineered with tags (e.g., His-tag, GST) for purification and detection. Its recombinant form aids in investigating interactions with binding partners, structural features (e.g., coiled-coil domains), and post-translational modifications. Researchers utilize it to generate antibodies, map epitopes, or study its role in cell proliferation assays and disease models.

Current challenges include clarifying FAM110B's physiological substrates, signaling pathways, and tissue-specific functions. Its recombinant version is pivotal for addressing these gaps, offering tools for biochemical assays (e.g., pull-down, kinase assays) and structural studies (e.g., crystallography). Further exploration of FAM110B could unveil its potential as a biomarker or therapeutic target, particularly in cancers where its expression correlates with prognosis. Overall, recombinant FAM110B serves as a critical reagent to decode its biological significance and therapeutic relevance.