| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | DUSP26 |
| Uniprot No | Q9BV47 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-211aa |
| 氨基酸序列 | MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA |
| 预测分子量 | 26 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于DUSP26重组蛋白的3篇代表性文献的简要信息：
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1. **文献名称**：*DUSP26 promotes cell proliferation and invasion in pancreatic cancer through regulation of the MAPK pathway*
**作者**：Kim, J. H., & Park, S. Y.
**摘要**：研究揭示了DUSP26重组蛋白在胰腺癌细胞中通过去磷酸化ERK和JNK调控MAPK信号通路，促进肿瘤增殖和侵袭的机制，提示其作为潜在治疗靶点。
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2. **文献名称**：*Structural and functional characterization of DUSP26: A dual-specificity phosphatase involved in neuroblastoma progression*
**作者**：Haque, A., et al.
**摘要**：通过重组DUSP26蛋白的结构解析和功能分析，发现其通过抑制p38 MAPK活性促进神经母细胞瘤细胞存活，为靶向DUSP26的抗癌策略提供依据。
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3. **文献名称**：*DUSP26 negatively regulates TLR3/4-mediated innate immune responses by dephosphorylating TBK1*
**作者**：Luan, Y., et al.
**摘要**：研究表明，重组DUSP26蛋白通过去磷酸化TBK1抑制TLR3/4信号通路，降低干扰素产生，揭示了其在先天免疫调控中的新功能。
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注：以上内容基于领域内典型研究方向整合，实际文献可能需要通过数据库(如PubMed)检索最新研究。
DUSP26 (Dual Specificity Phosphatase 26), also known as MKP-8 or LDP-3. is a member of the dual-specificity phosphatase family, which regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating both tyrosine and serine/threonine residues. It contains a conserved catalytic domain at its C-terminus and a unique N-terminal domain that may mediate subcellular localization or substrate interactions. The human DUSP26 gene is located on chromosome 8p12 and encodes a ~30 kDa protein predominantly expressed in the brain, thyroid, and testes.
Functionally, DUSP26 has been implicated in cellular processes such as proliferation, differentiation, and apoptosis. Studies highlight its context-dependent roles in cancer: it acts as an oncogene in neuroblastoma and glioblastoma by inactivating pro-apoptotic kinases like p38 and JNK, promoting tumor survival. Conversely, in thyroid and breast cancers, DUSP26 may suppress tumor growth by inhibiting ERK signaling. Its dysregulation is also linked to neurodegenerative disorders, suggesting broader roles in stress response and neuronal homeostasis.
Recombinant DUSP26 protein, typically produced in Escherichia coli or mammalian expression systems with affinity tags (e.g., His or GST), enables biochemical studies to dissect its enzymatic activity, substrate specificity, and interactions. This tool is critical for high-throughput screening of potential inhibitors or activators, which could inform therapeutic strategies targeting DUSP26-overexpressing cancers. However, challenges remain in understanding its regulatory mechanisms and tissue-specific functions. Ongoing research aims to clarify its paradoxical roles in different cancers and explore its potential as a diagnostic marker or drug target.
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