| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RPL36AL |
| Uniprot No | Q969Q0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-106aa |
| 氨基酸序列 | MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGRRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF |
| 预测分子量 | 39.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于RPL36AL重组蛋白的3篇文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询)：
1. **文献名称**: "Cloning and Characterization of Human RPL36AL: A Ribosomal Protein with Potential Extraribosomal Functions"
**作者**: Smith J, et al.
**摘要**: 本研究克隆并表达了RPL36AL重组蛋白，发现其不仅参与核糖体亚基的组装，还在体外实验中表现出与肿瘤抑制蛋白p53的相互作用，提示其可能参与细胞应激反应的调控。
2. **文献名称**: "Expression and Purification of Recombinant RPL36AL for Structural Studies"
**作者**: Chen L, et al.
**摘要**: 通过大肠杆菌表达系统成功纯化RPL36AL重组蛋白，并利用X射线晶体学解析其三维结构，揭示了该蛋白在核糖体mRNA通道中的潜在作用位点。
3. **文献名称**: "RPL36AL as a Novel Biomarker in Hepatocellular Carcinoma: Insights from Recombinant Protein-Based Assays"
**作者**: Wang Y, et al.
**摘要**: 通过重组RPL36AL蛋白制备抗体，发现其在肝癌组织中表达显著上调，进一步实验表明其过表达促进肝癌细胞增殖，提示其可作为治疗靶点。
如需具体文献，建议在PubMed、Google Scholar等平台以关键词“RPL36AL recombinant protein”检索最新研究。
**Background of RPL36AL Recombinant Protein**
The RPL36AL (Ribosomal Protein L36a-like) gene encodes a protein belonging to the L36 ribosomal protein family, which is a component of the 60S large ribosomal subunit. This gene is considered a paralog of RPL36A, sharing high sequence homology but differing in regulatory elements and expression patterns. RPL36AL is thought to play a role in ribosome biogenesis or translational regulation, though its precise molecular function remains less characterized compared to its counterpart.
Interest in RPL36AL stems from its potential involvement in cellular stress responses and disease pathways. Studies suggest it may interact with p53. linking ribosomal stress to cell cycle control or apoptosis. Dysregulation of ribosomal proteins, including RPL36AL, has been implicated in cancers, such as hepatocellular carcinoma and breast cancer, where altered expression correlates with tumor progression or chemoresistance.
The recombinant RPL36AL protein is produced via heterologous expression systems (e.g., *E. coli* or mammalian cells*) to enable functional and structural studies. Its recombinant form allows researchers to investigate protein-protein interactions, ribosome assembly mechanisms, and its role in pathological conditions. Additionally, it serves as a tool for developing diagnostic biomarkers or therapeutic strategies targeting ribosomal dysfunction.
Despite its emerging significance, further research is needed to clarify RPL36AL's specific contributions to ribosome biology and disease, highlighting the importance of recombinant protein tools in advancing this field.
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