Mouse Monoclonal LYN Antibody

The LYN antibody is a crucial tool for studying LYN kinase, a member of the SRC family of non-receptor tyrosine kinases. LYN plays dual roles in cellular signaling, acting as both a positive and negative regulator depending on context. It is predominantly expressed in hematopoietic cells, where it participates in immune receptor signaling, including B-cell receptor (BCR) and cytokine receptor pathways. Phosphorylation at specific tyrosine residues (e.g., Y396 for activation, Y507 for inhibition) tightly regulates its activity. Dysregulation of LYN has been implicated in various diseases, particularly cancers (e.g., chronic lymphocytic leukemia, breast cancer) and autoimmune disorders like systemic lupus erythematosus (SLE). Overactive LYN contributes to uncontrolled cell proliferation and survival in malignancies, while its impaired function may disrupt immune tolerance. LYN antibodies are widely used in research to detect protein expression, activation status (via phospho-specific variants), and interaction partners through techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Therapeutic strategies targeting LYN, including small-molecule inhibitors and monoclonal antibodies, are under investigation, highlighting the antibody's diagnostic and translational relevance. Recent studies also explore LYN's role in tumor microenvironment modulation and drug resistance mechanisms.