Mouse Monoclonal EphA7 Antibody

The EphA7 antibody is a research tool designed to target the EphA7 receptor, a member of the Eph receptor tyrosine kinase family, which plays critical roles in cell-cell communication and tissue patterning. Eph receptors, divided into EphA and EphB subclasses, bind membrane-anchored ephrin ligands to regulate processes like cell adhesion, migration, and boundary formation during embryonic development. EphA7 is notably involved in neural development, including axon guidance, synaptic plasticity, and cortical layering, as well as vascular and immune system regulation. In adults, EphA7 expression is more restricted but persists in tissues like the brain, kidneys, and lungs. Dysregulation of EphA7 has been linked to cancer, where it exhibits dual roles as either a tumor suppressor or promoter depending on context. For instance, EphA7 downregulation is observed in gliomas and colorectal cancers, while overexpression correlates with aggressive phenotypes in other malignancies. EphA7 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to study its expression patterns, signaling mechanisms, and interactions with ephrin-A ligands. These antibodies also aid in exploring EphA7's therapeutic potential, particularly in developing targeted therapies for cancers and neurological disorders. Recent studies highlight its role in modulating tumor microenvironments and immune responses, making EphA7 a focus for biomarker discovery and precision medicine.