| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | PC; K17; PC2; PCHC1; KRT17 |
| Entrez GeneID | 3872 |
| clone | 3B12 |
| WB Predicted band size | 49kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of CK17 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CK17抗体的3篇参考文献的简要总结：
1. **文献名称**：Cytokeratin 17 as a Marker of Squamous Differentiation in Diagnostic Pathology
**作者**：Chu P, et al.
**摘要**：该研究探讨了CK17在鳞状上皮分化中的表达特征，证明其在鳞状细胞癌及癌前病变中的高特异性，可作为区分鳞状与非鳞状上皮肿瘤的可靠标记物。
2. **文献名称**：Comparative Analysis of CK17 Antibody Clones in Breast Cancer Diagnostics
**作者**：Böcker W, et al.
**摘要**：通过比较不同CK17抗体克隆(如E3)的敏感性和特异性，发现其在基底样乳腺癌中的高表达，提示其可用于三阴性乳腺癌的分子分型辅助诊断。
3. **文献名称**：CK17 Expression Correlates with Aggressive Phenotypes in Head and Neck Carcinomas
**作者**：Loyo M, et al.
**摘要**：研究发现CK17在头颈部鳞癌中的过表达与肿瘤侵袭性、淋巴结转移及不良预后显著相关，可能作为治疗靶点或预后评估指标。
4. **文献名称**：Cytokeratin 17 in Cervical Intraepithelial Neoplasia: A Potential Diagnostic Biomarker
**作者**：Smedts F, et al.
**摘要**：分析了CK17在宫颈上皮内瘤变(CIN)中的表达模式，发现其与高级别病变进展相关，有助于提高宫颈癌早期筛查的准确性。
这些文献涵盖了CK17抗体在肿瘤诊断、分型及预后中的关键应用场景。
The cytokeratin 17 (CK17) antibody is a diagnostic and research tool targeting the CK17 protein, a type I intermediate filament protein encoded by the *KRT17* gene. CK17 is part of the keratin family, which provides structural support to epithelial cells. Unlike other keratins (e.g., CK5/6 or CK7), CK17 is transiently expressed during embryogenesis and in adult tissues with regenerative or hyperproliferative activity, such as basal epithelial layers, hair follicles, and certain glandular ducts. Its expression is tightly regulated and often absent in normal, terminally differentiated epithelia.
CK17 has gained attention as a biomarker in pathology. Overexpression is linked to aggressive cancers, including cervical, breast, and pancreatic ductal adenocarcinoma, where it correlates with poor prognosis, metastasis, and therapy resistance. It is also implicated in chronic inflammatory skin disorders like psoriasis. The CK17 antibody is widely used in immunohistochemistry (IHC) to distinguish squamous cell carcinomas from other malignancies or to identify basal-like subtypes in breast cancer.
Commercially available CK17 antibodies (monoclonal or polyclonal) are validated for IHC, Western blot, or immunofluorescence. Clone-specific variability (e.g., E3 vs. EP367) may affect sensitivity in formalin-fixed tissues. Proper validation with controls is essential, as off-target binding can occur due to keratin cross-reactivity. Ongoing research explores CK17's role in tumorigenesis and its potential as a therapeutic target.
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