| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | URG; HOMG4; EGF |
| Entrez GeneID | 1950 |
| clone | 9D7F11 |
| WB Predicted band size | 134kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human EGF expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是3-4条关于EGF抗体的参考文献概览(基于公开研究数据整理，非真实文献，仅供示例参考)：
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1. **文献名称**：*Therapeutic Targeting of EGFR with Monoclonal Antibodies in Solid Tumors*
**作者**：Burtness, B. et al.
**摘要**：探讨抗EGFR单抗(如西妥昔单抗)在结直肠癌、头颈癌等实体瘤中的临床应用，分析其通过阻断EGFR信号通路抑制肿瘤生长的机制及耐药性挑战。
2. **文献名称**：*Structural Basis of EGF Receptor Recognition by Therapeutic Antibodies*
**作者**：Ogiso, H. et al.
**摘要**：通过X射线晶体学解析抗EGFR抗体(如帕尼单抗)与EGFR胞外域的结合模式，揭示抗体特异性识别EGFR表位并抑制配体结合的分子机制。
3. **文献名称**：*Resistance Mechanisms to Anti-EGFR Antibodies in Cancer Therapy*
**作者**：Bianco, R. & Tortora, G.
**摘要**：综述抗EGFR单抗治疗中常见的耐药机制，包括EGFR突变、下游信号通路激活(如KRAS突变)及旁路信号代偿，并提出联合靶向策略。
4. **文献名称**：*Development of a High-Sensitivity ELISA for EGF Detection Using Anti-EGF Nanobodies*
**作者**：Ye, Z. & Chen, X.
**摘要**：报道一种基于抗EGF纳米抗体的新型免疫检测技术，其通过优化抗体亲和力与标记方法显著提高EGF检测灵敏度，适用于早期癌症诊断研究。
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注：以上为模拟示例，实际文献需通过PubMed、Web of Science等学术平台检索。如需真实文献，建议补充具体研究方向(如癌症治疗、检测方法等)以便精准推荐。
Epidermal Growth Factor (EGF) antibodies are immunological tools designed to target EGF, a small protein critical for regulating cell proliferation, differentiation, and survival. EGF binds to the epidermal growth factor receptor (EGFR) on cell surfaces, activating signaling pathways like MAPK and PI3K-Akt, which drive cellular growth. Dysregulation of EGF/EGFR signaling is implicated in cancers, inflammatory diseases, and tissue repair disorders, making it a key therapeutic and diagnostic focus.
EGF antibodies are typically monoclonal or polyclonal. Monoclonal antibodies, such as cetuximab, block EGFR signaling with high specificity, offering therapeutic benefits in cancers like colorectal and head/neck carcinomas. Polyclonal antibodies, often used in research, detect EGF in assays (e.g., ELISA, Western blot) to study its expression and localization.
In research, EGF antibodies help elucidate EGF's role in physiological processes (e.g., wound healing) and pathologies (e.g., tumor progression). They also aid in developing diagnostic kits to quantify EGF levels in clinical samples. Challenges include minimizing off-target effects in therapies and improving antibody affinity. Overall, EGF antibodies remain vital for advancing both basic science and clinical applications.
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