Mouse Monoclonal GABBR2 Antibody

The GABBR2 antibody is a research tool designed to detect and study the GABA B receptor subunit 2 (GABBR2), a critical component of the GABA_B receptor, a class of G protein-coupled receptors (GPCRs) that mediate the inhibitory effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the mammalian central nervous system. The GABA_B receptor functions as a heterodimer, requiring both GABBR1 and GABBR2 subunits for proper trafficking, cell surface expression, and signal transduction. GABBR2 plays a pivotal role in coupling the receptor to intracellular effector systems, such as G proteins, which regulate potassium and calcium channels, adenylyl cyclase, and other downstream pathways. This receptor is implicated in modulating synaptic transmission, neuronal excitability, and long-term plasticity. Dysregulation of GABBR2 has been linked to neurological and psychiatric disorders, including epilepsy, anxiety, depression, and addiction. Antibodies targeting GABBR2 are widely used in neuroscience research to investigate receptor localization, expression levels, and functional interactions in brain tissues or cell models. They are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of GABA_B receptor biology and its therapeutic potential. Specificity and validation of GABBR2 antibodies are crucial, as cross-reactivity with related proteins can confound results.