| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099 |
| Entrez GeneID | 9568 |
| clone | 5G7F7 |
| WB Predicted band size | 105.8kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GABBR2 (AA: 319-483) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GABBR2抗体的参考文献示例(注：内容为概括性示例，建议通过PubMed或Google Scholar验证真实文献)：
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1. **"Development and characterization of a specific antibody for GABBR2 receptor subunit"**
*Authors: Smith A, et al.*
摘要：本研究报道了一种新型兔源多克隆抗体的开发，该抗体特异性靶向GABBR2受体亚基。通过免疫印迹和免疫组化验证，证明其在啮齿类动物及人类脑组织中的高特异性，为研究GABBR2在中枢神经系统的表达分布提供了工具。
2. **"GABBR2 expression in autism spectrum disorder: Insights from post-mortem brain analysis"**
*Authors: Chen L, et al.*
摘要：利用GABBR2特异性抗体对自闭症患者脑组织进行免疫染色，发现皮层和海马区GABBR2蛋白表达显著下调，提示GABBR2异常可能与自闭症的突触功能障碍相关。
3. **"Role of GABBR2 in epilepsy: Antibody-based detection in rodent models"**
*Authors: Tanaka K, et al.*
摘要：通过Western blot和免疫荧光技术，结合抗GABBR2抗体，发现癫痫模型小鼠海马区GABBR2表达动态变化，表明其在抑制性信号通路中起关键作用，可能成为治疗靶点。
4. **"GABBR2 antibody validation for flow cytometry in immune cells"**
*Authors: Müller S, et al.*
摘要：本文验证了商用GABBR2抗体在流式细胞术中的应用，证实其在T细胞和树突状细胞表面的表达，拓展了GABBR2在免疫调控研究中的潜在作用。
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建议通过学术数据库检索真实文献，关键词：**GABBR2 antibody + specific application(e.g., Western blot, neurodevelopmental disorders)**。
The GABBR2 antibody is a crucial tool for studying the GABA B receptor subunit 2 (GABBR2), a component of the GABA B receptor, a class C G-protein-coupled receptor (GPCR) central to inhibitory neurotransmission. GABA B receptors function as heterodimers, requiring both GABBR1 and GABBR2 subunits for proper trafficking and signaling. GABBR2 plays a key role in coupling receptor activation to downstream effectors, such as G proteins and ion channels, modulating synaptic transmission, neuronal excitability, and long-term plasticity. It is widely expressed in the central and peripheral nervous systems, influencing processes like anxiety, pain perception, and cognitive function.
Antibodies targeting GABBR2 enable researchers to investigate its expression, localization, and interactions in tissues and cell models. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study receptor distribution under physiological and pathological conditions. Dysregulation of GABBR2 has been implicated in neurological and psychiatric disorders, including epilepsy, schizophrenia, and addiction, making it a potential therapeutic target.
Commercial GABBR2 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Specificity is validated through knockout controls or siRNA knockdowns. Researchers must verify antibody performance in their experimental systems due to potential cross-reactivity with related proteins or tissue-specific isoforms. These tools advance our understanding of GABA B receptor biology and its role in disease mechanisms.
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