| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GXII; ROSSY; PLA2G12 |
| Entrez GeneID | 81579 |
| clone | 7C7C9 |
| WB Predicted band size | 21kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PLA2G12A (AA: 21-189) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PLA2G12A抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*"Secreted phospholipase A2 group XIIA modulates hepatitis C virus replication through its enzymatic activity"*
**作者**：Li et al.
**摘要**：研究利用PLA2G12A特异性抗体，发现该酶通过水解宿主细胞膜磷脂促进丙型肝炎病毒(HCV)复制，抗体阻断实验表明其酶活性对病毒生命周期至关重要。
2. **文献名称**：*"Structural and functional characterization of PLA2G12A in lipoprotein metabolism"*
**作者**：Wang et al.
**摘要**：通过PLA2G12A抗体进行免疫沉淀和体外功能实验，揭示该蛋白通过调控脂蛋白颗粒的组装与分泌影响血浆脂质水平，可能与心血管疾病相关。
3. **文献名称**：*"PLA2G12A as a novel biomarker for hepatocellular carcinoma: Validation by immunohistochemistry"*
**作者**：Zhang et al.
**摘要**：研究开发了高特异性PLA2G12A单克隆抗体，用于肝细胞癌(HCC)组织检测，发现其表达水平与肿瘤进展和预后显著相关，提示其作为诊断标志物的潜力。
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以上研究均涉及PLA2G12A抗体的应用，涵盖病毒复制、脂代谢调控及癌症诊断等领域。如需全文链接或补充信息，可进一步提供具体方向。
PLA2G12A (phospholipase A2 group XIIA) is a secreted phospholipase A2 enzyme encoded by the PLA2G12A gene. It plays a role in lipid metabolism, particularly in regulating lipoprotein remodeling and high-density lipoprotein (HDL) assembly. Unlike other phospholipases, PLA2G12A exhibits unique substrate specificity and is involved in modulating hepatic very-low-density lipoprotein (VLDL) secretion, linking it to lipid homeostasis and metabolic disorders. Research has associated PLA2G12A dysregulation with pathological conditions, including viral hepatitis, atherosclerosis, and cancer. Notably, its overexpression in hepatocellular carcinoma suggests a potential role in tumor progression and microenvironment modulation.
PLA2G12A antibodies are tools used to detect, quantify, or inhibit this protein in research and diagnostic contexts. They enable studies on PLA2G12A’s enzymatic activity, cellular localization, and interactions with lipid substrates or receptors. In virology, such antibodies help investigate PLA2G12A’s interaction with hepatitis viruses and SARS-CoV-2. as the enzyme may influence viral entry or replication. Therapeutic applications are under exploration, with antibody-based strategies targeting PLA2G12A’s pro-inflammatory or lipid-modifying functions. However, challenges remain in developing highly specific antibodies due to structural similarities within the phospholipase family. Ongoing research aims to clarify PLA2G12A’s dual roles in lipid signaling and disease pathogenesis, positioning it as a biomarker or therapeutic target for metabolic and inflammatory disorders.
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