| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MKBP; HSP27; Hs.78846; LOH11CR1K |
| Entrez GeneID | 3316 |
| clone | 4B9E2 |
| WB Predicted band size | 20.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HSPB2 (AA: 1-182) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HSPB2抗体的模拟参考文献示例(部分信息为假设性概括，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *HSPB2 Expression in Skeletal Muscle Atrophy: A Protective Role*
**作者**: Smith J, et al. (2020)
**摘要**: 本研究通过特异性HSPB2抗体发现，在肌肉萎缩模型中HSPB2表达显著上调，免疫荧光显示其定位于肌纤维线粒体周围，提示其可能通过抑制细胞凋亡参与保护机制。
2. **文献名称**: *HSPB2 Aggregation in Neurodegenerative Disorders*
**作者**: Chen L, et al. (2018)
**摘要**: 利用HSPB2多克隆抗体进行脑组织免疫组化分析，发现阿尔茨海默病患者脑内HSPB2异常聚集，可能与tau蛋白病理相关，提示其参与神经退行性病变调控。
3. **文献名称**: *Development of a Monoclonal Antibody for HSPB2 Detection in Human Cardiomyocytes*
**作者**: Jones R, et al. (2015)
**摘要**: 报道了一种新型HSPB2单克隆抗体的制备与验证，该抗体在Western blot和免疫沉淀中表现出高特异性，成功应用于心肌缺血再灌注损伤模型中HSPB2的动态表达分析。
4. **文献名称**: *HSPB2 as a Biomarker in Diabetic Nephropathy*
**作者**: Zhang Y, et al. (2021)
**摘要**: 通过HSPB2抗体检测糖尿病肾病患者肾脏组织，发现HSPB2与氧化应激标记物共定位，提示其可能作为肾脏纤维化的潜在生物标志物及治疗靶点。
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**注意**：以上为示例性内容，实际文献需通过PubMed、Web of Science等平台检索确认。如需精准文献，建议使用关键词"HSPB2 antibody"并结合研究领域(如神经、肌肉疾病)进一步筛选。
HSPB2. also known as heat shock protein beta-2. is a member of the small heat shock protein (sHSP) family, characterized by its conserved α-crystallin domain. It functions as a molecular chaperone, assisting in protein folding, preventing aggregation under stress conditions, and maintaining cellular homeostasis. HSPB2 is constitutively expressed in various tissues, with higher levels observed in skeletal muscle, heart, and the nervous system. It plays a role in protecting cells from oxidative stress, apoptosis, and ischemia-reperfusion injury.
HSPB2 is closely associated with HSPB1 (HSP27), often forming heterocomplexes to enhance chaperone activity. Studies link HSPB2 to neurodegenerative diseases (e.g., ALS, Alzheimer’s), muscular dystrophies, and cardiovascular disorders. Its dysregulation may contribute to disease progression by disrupting protein quality control or stress response pathways.
HSPB2 antibodies are essential tools for detecting and quantifying HSPB2 expression in research. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its localization, expression patterns, and interactions in disease models. Specific antibodies help distinguish HSPB2 from other sHSPs, aiding investigations into its unique roles in cellular stress mechanisms and therapeutic targeting. Validation for specificity is critical, as cross-reactivity with homologous proteins (e.g., HSPB1) can occur due to structural similarities.
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