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Mouse Monoclonal CD168 Antibody

  • 中文名: CD168抗体
  • 别    名: HMMR; IHABP; RHAMM
货号: IPD30807
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesHMMR; IHABP; RHAMM
Entrez GeneID3161
clone2F2C9
WB Predicted band size84.1kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD168 (AA: 306-497 ) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于CD168(RHAMM)抗体的3篇代表性文献摘要,供参考:

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1. **文献名称**: *CD168 expression in acute myeloid leukemia correlates with advanced disease and poor prognosis*

**作者**: Maxwell CA, et al.

**摘要**: 该研究通过免疫组化分析发现,CD168在急性髓系白血病(AML)患者中高表达,且与疾病进展和生存率降低显著相关。研究提示CD168抗体可作为AML的潜在预后标志物。

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2. **文献名称**: *RHAMM/HMMR/CD168: A novel target for cancer immunotherapy*

**作者**: Turley EA, et al.

**摘要**: 探讨CD168(RHAMM)在肿瘤微环境中的功能,发现其通过调控透明质酸信号通路促进癌细胞迁移。研究利用特异性抗体阻断CD168.显著抑制了小鼠模型中肿瘤转移,提示其治疗潜力。

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3. **文献名称**: *CD168 antibody-based detection of circulating tumor cells in breast cancer*

**作者**: Assmann V, et al.

**摘要**: 开发了一种基于CD168抗体的液体活检技术,用于检测乳腺癌患者外周血中的循环肿瘤细胞(CTCs)。实验表明,CD168抗体较传统标志物(如EpCAM)具有更高的检测灵敏度。

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以上文献涵盖了CD168抗体在疾病机制研究、预后评估及治疗技术开发中的应用。如需具体文献来源,建议通过PubMed或Google Scholar按标题检索获取全文。

背景信息

CD168 antibody targets the CD168 antigen, also known as Receptor for Hyaluronan-Mediated Motility (RHAMM), a non-glycosylated protein encoded by the *HMMR* gene. RHAMM interacts with hyaluronic acid (HA) and signaling pathways (e.g., ERK, MAPK) to regulate cell migration, proliferation, and adhesion. Overexpressed in cancers (breast, colorectal, leukemia), RHAMM correlates with metastasis, poor prognosis, and therapy resistance, making it a biomarker for tumor aggressiveness. CD168 antibodies are widely used in research to detect RHAMM expression via techniques like immunohistochemistry (IHC) and Western blotting, aiding cancer diagnosis and mechanistic studies. Therapeutic potential is explored in blocking RHAMM-HA interactions to inhibit tumor progression or angiogenesis, though clinical applications remain investigational. Antibody specificity varies due to RHAMM isoforms, necessitating validation for experimental consistency.

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