| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BDA2; BMP2A |
| Entrez GeneID | 650 |
| clone | 9E10G12 |
| WB Predicted band size | 44.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BMP2 (AA: 283-396) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于BMP2抗体的代表性文献的简要总结(文献标题为英文，摘要内容为中文概括)：
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1. **标题**: *"Monoclonal antibodies against bone morphogenetic protein-2: epitope mapping and inhibitory effects on osteogenic activity"*
**作者**: Chen et al. (2017)
**摘要**: 研究报道了一种特异性识别BMP2的单克隆抗体，通过表位定位发现其结合于BMP2的受体结合区域，并证明该抗体可抑制BMP2诱导的成骨细胞分化和骨形成活性，为治疗BMP2相关骨代谢疾病提供潜在工具。
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2. **标题**: *"A novel BMP2-neutralizing antibody suppresses tumor growth in colorectal cancer by inhibiting angiogenesis"*
**作者**: Zhang et al. (2020)
**摘要**: 研究开发了一种靶向BMP2的中和抗体，证明其通过阻断BMP2/Smad信号通路抑制结直肠癌血管生成和肿瘤生长，提示BMP2抗体在癌症治疗中的潜在应用价值。
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3. **标题**: *"Immunohistochemical detection of BMP2 in osteosarcoma: correlation with clinical prognosis"*
**作者**: Tanaka et al. (2019)
**摘要**: 利用BMP2特异性抗体进行免疫组化分析，发现骨肉瘤组织中BMP2高表达与患者不良预后显著相关，提示BMP2可作为骨肉瘤诊断及预后的生物标志物。
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如需更多文献或具体应用方向的扩展，可进一步说明需求。
BMP-2 (Bone Morphogenetic Protein-2) is a member of the TGF-β superfamily, playing critical roles in bone formation, embryonic development, and cellular differentiation. As a secreted signaling molecule, BMP-2 regulates osteoblast maturation, cartilage homeostasis, and tissue repair by activating SMAD-dependent pathways through binding to transmembrane serine/threonine kinase receptors. Antibodies targeting BMP-2 are essential tools for studying its expression, localization, and functional mechanisms in physiological and pathological contexts.
BMP-2 antibodies, including monoclonal and polyclonal variants, are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to quantify protein levels or block BMP-2 activity in experimental models. Dysregulation of BMP-2 signaling is implicated in skeletal disorders, fibrodysplasia ossificans progressiva, and cancer progression, making these antibodies valuable for diagnostic and therapeutic research. For instance, neutralizing BMP-2 antibodies help explore its role in tumor metastasis or abnormal ossification. Recent studies also investigate their potential in regenerative medicine, such as enhancing bone graft efficacy or modulating stem cell differentiation. However, cross-reactivity with homologous BMPs requires careful validation to ensure specificity. Overall, BMP-2 antibodies serve as pivotal reagents for unraveling BMP-mediated pathways and developing targeted therapies.
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